摘要
目的:探讨吉西他滨联合多西他赛治疗晚期软组织肉瘤的临床疗效。方法:收集11例对一线化疗药物耐药的晚期软组织肉瘤患者,应用吉西他滨(剂量为900mg/m^2,第1和第8天)联合多西他赛(剂量为100 mg/m^2,第8天)每3周重复给药。如患者曾经接受放疗,吉西他滨剂量减为675 mg/m^2,多西他赛剂量减为75mg/m^2。结果:接受化疗的患者总有效率(CR+PR+SD)为54.5%。中位随访时间为19(1~36)个月,中位总生存期为15.4个月(95%CI:8.012~21.598)和中位无进展生存期为8.4个月(95%CI:7.342~8.768)。12个月和36个月的生存率分别是81.8%和27.3%。吉西他滨联合多西他赛治疗软组织肉瘤最常见的非血液学不良反应是黏膜炎,对症处理明显好转。结论:吉西他滨联合多西他赛作为二线化疗药物治疗晚期软组织肉瘤患者具有较好的临床疗效,且有较好的耐受性,本研究结论为该方案的大样本临床试验提供了依据。
Objective: To investigate the promising anti-tumor effects of gemcitabine and/or docetaxel on metastatic or unresect- able soft tissue sarcomas. Methods: Data of 11 patients with advanced soft tissue sarcomas refractory to first-line chemotherapy treat- ment were enrolled in this study. They received gemcitabine alone or gemcitabine/docetaxel combination as follows: 900 mg/m^2 gem- citabine on days 1 and 8, and 100 mg/m^2 docetaxel on day 8. The regimen was repeated every 3 weeks. When irradiation was conducted before drug therapy, the doses were reduced to 675 mg/m^2 gemcitabine on days 1 and 8, and 75 mg/m^2 docetaxel on day 8. The regimen was repeated every 3 weeks, Results: The gemcitabine/docetaxel combination was well tolerated. The most commonly observed hema- tologic toxicity of the combined therapy was neutropenia ( 45.5 % ). The most common non-hematologic toxicity observed was mucosi- tis ( 45.5 % ). The overall response was 45.5%. Follow-ups ranging from 1 month to 36 months ( median = 19 months ) revealed that the median overall survival time was 15.4 months ( 95% CI = 8.012 - 21.598 ) and the median progression-free survival time was 8.4 months ( 95 % CI = 7.342 - 8.768 ). The one- and two-year survival rates were 81.8 % and 27.3 %, respectively. Conclusion: A gem- citabine/docetaxel regimen as second-line treatment for patients with advanced soft tissues sarcomas is effective and has acceptable toxicities. These results should be evaluated in a large-sample Ⅲ trial.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2012年第12期853-856,共4页
Chinese Journal of Clinical Oncology
关键词
晚期软组织肉瘤
二线化疗
吉西他滨
多西他赛
Advanced soft tissue sarcomas
Second-line chemotherapy
Gemcitabine
Docetaxel