细胞电化学分析的研究进展

Research Progress in Electroanalysis of Cells

细胞是构成生命有机体的基本单位,对有机体的生长发育以及生理功能的维护起着至关重要的作用。由于细胞中的各种生理活动多伴随着电荷的定向传递、传导或者转移,因此,结合电分析化学技术的简单、便捷、灵敏以及快速的优势,细胞电分析化学逐渐发展成为了生物电分析化学的一个重要分支,为细胞活性分析、疾病诊治以及药物筛选等研究提供了越来越多的理论支持,并奠定了重要的实验基础。近几年,随着界面修饰技术、纳米技术、分子组装以及分子识别技术的发展,具有更高生物相容性和选择性的电极环境被开发应用于细胞的固定,极大地促进了细胞电分析化学的发展。本文重点评述近三年细胞电化学分析的研究进展,并以此为基础展望了其研究前景。

As the basic units of life organism,cells play a key role in the developmental and physiological process of the organism.Meanwhile,since the physiological activities of cells are usually coupled with electron transfer and/or eletroactive species transferring,electroanalytical method has proven to be a very useful technique for the study of cells,which will be beneficial to the assay of cell activity,disease diagnosis and drug screening.Moreover,with the development of surface modification,nanotechnology and molecular recognition,more and more modified electrodes with biocompatible surface have been fabricated for electroanalytical study of cells,which may open more opportunities for the study of cells.Therefore,electroanalysis of cells has received more and more research interests,and lots of achievements have been obtained by the colleagues in China and those in the other countries.Herein,we summarize the research progress of cell-based electroanalytical studies mostly in the recent three years to give a general overview to this field.