血胱抑素C在窒息新生儿肾损害的早期诊断意义

Significance of Serum Cystatin C in Early Diagnosis of Renal Damage of Newborns with Asphyxia

目的探讨血胱抑素C(cys-C)在窒息新生儿肾损害的早期诊断意义。方法选择符合诊断标准的窒息新生儿240例,按出生时Apgar评分分为轻度窒息144例,重度窒息96例,同期选择60例健康足月新生儿作为对照组。窒息新生儿在入院后第1天,对照组新生儿在出生后1～3 d抽取外周静脉血3 ml,分别检测血cys-C,尿素氮(Bun)和肌酐(Scr),并进行统计学分析。结果①轻度窒息组和重度窒息组血清cys-C均较对照组显著升高(P<0.01),重度窒息组血清cys-C较轻度窒息组显著升高(P<0.01);②轻度窒息组血清cys-C的异常率与Bun和Scr的异常率差异有统计学意义(均P<0.05),重度窒息组血清cys-C的异常率与Bun、Scr的异常率差异有统计学意义(均P<0.01)。结论血清cys-C可作为窒息新生儿肾功能损伤的早期诊断指标,在重度窒息组其敏感性高于血Bun、Scr。

Objective To explore the significance of serum cystatin C（cys-C） in early diagnosis of renal damage of newborns with asphyxia.Methods The 240 cases of newborns with asphyxia in accord with diagnostic criteria,including 144 cases of mild asphyxia and 96 cases of severe asphyxia by Apgar score were enrolled in this study.60 health individuals were chosen as control.3ml of peripheral venous blood was sampled to test the levels of cys-C,Bun and Scr,and the date was analyzed with statistical methods.Results ①The levels of cys-C in both mild asphyxia and severe asphyxia group were higher than that of the control group（P0.01）;And so did between the mild asphyxia and severe asphyxia group.②The difference between the abnormal rate of cys-C and Bun or Scr was statistical significance both in the mild asphyxia（all P0.05） and severe asphyxia group（all P0.01）.Conclusion The serum cys-C level can be used as the index for the early diagnosis of renal damage of newborns with asphyxia.Especially for the severe asphyxia newborns it is with a higher sensitivity as compared to Bun and Scr.