冠心病氯吡格雷抵抗的前瞻性研究

A Prospective Study on Clopidogrel Resistance in CHD

目的前瞻性探讨氯吡格雷抵抗(CR)与临床心脑血管事件(MACCE)的关系。方法对拟诊冠心病患者进行基线检测和随访,对比观察不同基线水平的血小板聚集抑制率(DPAI)值MACCE的发生危险。结果共调查并随访107例心内科住院患者,1年内MACCE发生率为23.8%;CR抵抗者的MACCE发生危险显著升高(OR=3.71,P=0.024),且随着CR水平的升高,MACCE发生危险逐级抬高,差异具有统计学意义(P=0.020)。MACCE组的DPAI值低于未发生MACCE组(14.7%±3.7%vs.27.9%±24.2%;P=0.074)。结论 CR可能是MACCE的一个预测因子。

Objective To prospectively explore the relationship between clopidogrel resistance（CR） and major adverse cardiac and cerebrovascular event（MACCE）.Methods The risk of MACCE in the different degree of platelet aggregation inhibition（DPAI） levels of a diagnosing CHD population was compared by baseline investigation and follow-up.Prospective case control study was carried out.Results In 107 cases of cardiovascular in-patients,the incidence of MACCE within one year was 23.8%;the risk of MACCE in patients with CR was significantly higher than those without CR（OR=3.71,P=0.024）,and increased with the level of CR（P=0.020）.DPAI in MACCE group was significantly lower than that in non-MACCE group（14.7%±3.7% vs 27.9%±24.2%;P=0.074）.Conclusion CR may act as a predictor to MACCE.