20例频发TIA患者降纤治疗临床分析

The Analysis of Urokinase in the Treatment of Frequent Transient Ischemic Attack on Twenty Patients

目的探讨并分析比较频繁发作短暂性脑缺血发作(TIA)患者采用尿激酶降纤治疗与普通常规治疗方案的临床疗效。方法 40个临床病例根据患者及其家属同意后分组,实验组患者进行尿激酶早期降纤治疗,同时加用对照组治疗方案,对照组单纯采用抗血小板聚集、调脂稳定血管内膜斑块治疗,对两组在治疗后3,7,14 d的临床治愈率以及在1周、1周～1个月内、1～3个月TIA与脑梗死发率进行对比分析。结果早期给予降纤治疗的频繁发作TIA患者在不同观察时间段的临床治愈率明显高于对照组,且发展为脑梗死几率远小于对照组的患者(P<0.05),前者临床疗效显著。结论频繁发作TIA的临床患者早期给予尿激酶降纤治疗,可以在一定程度上提高临床治愈率,同时可以降低其发展为脑梗死几率,安全、有效。

Objective To investigate and analyze the efficacy of urokinase and normal methods in the treatment of frequent transient ischemic attack（TIA） patients.Methods Fourty patients were divided into two groups comply with patients＇ permitting.Urokinase were used in the treatment group,the control group was not treated with urokinase,only with normal meths,then analysis both two groups on 3,7,14 day and on 1 week,1 week-1 month,1 month-3 month.Results The efficacy of the treatment group was superior to the control group（P0.05） on different times,with little chance of developing Cerebral infarction.Conclusion On the basis of conventional therapy,adding urokinase for patients with TIA could be effective and reduce the rate of cerebral infarction,safely and effectively.