孟鲁司特钠治疗毛细支气管炎临床疗效观察

Clinical Observation of Meng Lu Montelukast Sodium in the Treatment of Bronchiolitis

目的探讨孟鲁司特钠治疗毛细支气管炎的临床疗效与安全性。方法对铜陵市第四人民医院儿科收住的90例毛细支气管炎患儿随机分为治疗组与对照组,两组均给予常规治疗。治疗组给予孟鲁司特钠口服,6个月以下2.5 mg/d,6个月以上4 mg/d,每晚1次,观察患儿咳嗽、气促、喘息、肺部体征改善时间及住院天数。结果治疗组治愈31例(68.9%),好转11例(24.4%),无效3例(6.7%),总有效率93.3%;对照组治愈23例(51.1%),好转13例(28.9%),无效9例(20%),总有效率80%。治疗组有效率(93.3%)明显高于对照组(80%),差异有统计学意义(χ2=3.462,P<0.05)。治疗组咳嗽、气促、喘息、肺部体征改善时间及住院天数较对照组明显缩短,差异有统计学意义(P<0.05)。结论孟鲁司特钠治疗毛细支气管炎疗效确切,安全可靠,值得临床推广使用。

Objective To explore the clinical efficacy and safety of Meng Lu montelukast sodium in the treatment of bronchiolitis.Methods To my department of pediatrics,90 cases of infants with bronchiolitis were randomly divided into treatment group and control group,two groups were given conventional treatment.The treatment group was given Meng Lu montelukast sodium oral,6 months following 2.5 mg/d,4 mg/d more than 6 months,every night 1,children with cough,wheezing,shortness of breath,pulmonary symptoms improved time and length of hospital stay were observed and recorded.Results 31 cases in treatment group were cured（68.9%）,improved in 11 cases（24.4%）,invalid in 3 cases（6.7%）,the total efficiency of 93.3%;23 cases in control group of were cured（51.1%）,improved in 13 cases（28.9%）,invalid in 9 cases（20%）,with the total efficiency of 80%.The effective rate of treatment group（93.3%） was significantly higher than that in control group（80%）,which had a significant difference（χ2=3.462,P0.05）.Cough,wheezing,shortness of breath,group of pulmonary symptoms improved time and length of hospital stay in treatment group were significantly shorter than those of control group,the difference was statistically significant（P0.05）.Conclusion Meng Lu montelukast sodium had curative effect,safety and reliability in treatment of capillary bronchitis,it was worthy of clinical use.