IMA在缺血性脑卒中早期诊断中的应用价值

The Value of Ischemia Modified Albumin in Early Diagnosis of Ischemic Cerebral Stroke

目的探讨缺血修饰白蛋白(Ischemic modified albumin,IMA)对急性缺血性脑卒中的早期诊断价值。方法在日立7600-110全自动生化分析仪上,用间接白蛋白钴结合(albumin cobalt binding,ACB)试验,检测86例急性缺血性脑卒中患者、52例缺血性脑卒中恢复期患者及30例正常对照者血清中缺血修饰白蛋白的浓度,计算其阳性率,进行比较分析。结果急性缺血性脑卒中患者血清中缺血修饰白蛋白阳性率为57.0%,与恢复期(3.8%)及正常对照(0)比较,其阳性率显著升高,差异有统计学意义(P<0.01),而恢复期患者血清中缺血修饰白蛋白阳性率为3.8%与正常对照(0)比较,其阳性率比较接近,差异无统计学意义(P>0.05),血清中缺血修饰白蛋白水平与其缺血程度呈正相关。结论检测缺血修饰白蛋白的水平对急性缺血性脑卒中的早期诊断有一定的临床应用价值。

Objective To investigate the value of early diagnosis of Ischemic modified albumin in patients with acute Ischemic Cerebral stroke.Methods Albumin cobalt binding（albumin cobalt binding,ACB） test was used with the Hitachi7600-110 full automatic biochemical analyzer to detect modified albumin concentration in serum among 86 cases of patients with acute ischemic stroke,52 cases of ischemic cerebral apoplexy convalescent patients and 30 normal controls of ischemia,its positive rate was calculated,comparative analysis was conducted.Results Patients with acute ischemic stroke of serum ischemia modified albumin in the positive rate was 57.0%,and the recovery period（3.8%） and normal controls（0）,the positive rates increased significantly,the difference was statistically significant（P0.01）,and the recovery period of ischemia modified albumin in serum of patients with positive rate of 3.8% and normal controls（0） comparison of positive rate,the closer,the difference was not statistically significant（P0.01）,serum ischemia-modified albumin levels were positively correlated with ischemia.Conclusion The detection of serum levels of IMA had important value in early diagnosis of ischemic cerebral stroke.