美沙拉嗪口服联合灌肠治疗溃疡性结肠炎的疗效评价

Clinical efficacy of mesalazine oral combined with enema on ulcerative colitis

目的评价美沙拉嗪口服联合灌肠治疗溃疡性结肠炎(UC)的临床疗效。方法将120例UC患者随机分为治疗组和对照组,对照组给予口服美沙拉嗪缓释颗粒;治疗组在此基础上,同时给予美沙拉嗪灌肠剂保留灌肠。疗程均为4周。结果治疗组总有效率96.7%,明显高于对照组的68.3%(P<0.05)。治疗后结肠镜检查结果及血清C-反应蛋白(CRP)、纤维蛋白原(Fib)、平均血小板体积(MPV)的水平治疗组与对照组比较,差异均有统计学意义(P<0.05)。治疗组与对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论美沙拉嗪口服联合灌肠治疗溃疡性结肠炎疗效确切,安全性好,值得推广。

Objective To evaluate the clinical efficacy of mesalazine oral combined with enema on ulcerative colitis.Methods 120 cases of ulcerative colitis were randomly divided into therapy group（60 cases）and control group（60 cases）.The control group was given mesalazine release granules,the therapy group was given mesalazine enema on the basis of control group.The treatment period lasted for 4 weeks.Results The general efficiency rate of treatment group was 96.7%,the control group was 68.3%.The difference between the two groups was significant（P0.05）.The colon lens check-up result and the serum levels of CRP,Fib and MPV of the two groups after the treatment were siginificant（P0.05）.There was no significant difference in adverse reaction between the two groups（P0.05）.Conclusion The clinical curative effects of mesalazine oral combined enema on UC is significant and safe,it is worthy of clinical application.