穿心莲有效部位Poloxamer188聚合物胶束的制备工艺

Preparation and formulation of poloxamer188 loaded effective parts of andrographis paniculata nees polymeric micelles

目的制备Poloxamer188穿心莲有效部位的聚合物胶束。方法薄膜水化法制备穿心莲有效部位聚合物胶束,正交设计优化处方工艺。HPLC法测定其载药量和包封率,激光粒度仪测定粒径。结果载药胶束包封率为(85.7+2.1)%,载药量为(1.11+0.09)%,粒径为(198.32+3.35)nm。结论载药Poloxamer188胶束制备工艺简便易行,为中药制剂提供了新剂型。

To prepare the capsule of poloxamer188 polymeric micelles system loaded with effective parts of androg- raphis paniculata nees （AEP）. Methods AEP loaded Poloxamer188 micelles were prepared by thin film hydration method. The main factors affecting the drug-loading encapsulation ratio was studied by single factor analysis and op- timization preparation condition was gained by orthogonal design. The drug-loading coefficient and encapsulation ef- ficiency of AEP in micelles were determined by HPLC. The mean particle size was determined by Zetasizer H-3000 Laser Particle Size Analyzer. Results The encapsulation efficiency and drug loading coefficient were （85.7＋2.1） and（1.11＋0.09）%, respectively. The diameter was （198.32＋3.35） nm. Conclusion The process is practical and simple for the preparation of AEP loaded Poloxamer188 micelles. It is a new method for the preparation of Chi- nese Traditional Medicine.