某市支原体感染及与HIV共感染后支原体耐药性分析

Analysis for the mycoplasma drug resistance after the co-infection of mycoplasma and HIV in certain city

目的了解某市支原体感染状况,分析本地区支原体的耐药性情况,初步探讨支原体和HIV共感染对支原体耐药性的关系和影响,指导临床合理用药。方法采用支原体的分离鉴定与药敏试剂盒检测分析支原体的耐药性。结果 856例艾滋病阳性中共检测出支原体26例;546例性病门诊标本中,解脲支原体(UU)、人型支原体(MH)的检出率分别为44.13%、7.88%,男性支原体感染率28.63%,明显低于女性(71.36%),两者阳性率有显著性差舁P<0.01。药敏试验结果显示,支原体的耐药性与HIV共感染没有相关性,UU、MH和UU+MH对药物的敏感性最高者为交沙霉素和强力霉素,UU对螺旋霉素、环丙沙星高度耐药,MH及UU+MH则对螺旋霉素、氧氟沙星耐药性高。结论支原体的治疗与HIV病毒共感染没有明显相关性,本地区支原体感染以UU为主,UU+MH混合感染率也很高。治疗本地区泌尿生殖道支原体感染可首选交沙霉素与强力霉素。

Objective To understand the Kaifeng myeoplasma infection status, to analyze the mycoplasma drug resistance in some region, to preliminarily discuss the impact and the relationship of the mycoplasma and HIV coinfection on the myeoplasma drug resistance in order to guide the clinical rational drug use. Methods The mycoplasma drug resistance were detected and analyzed with the methods of mycoplasma separation appraisal drug sensitive test kit. Results 26 cases of 856 cases of HIV positive were determined to be infected with mycoplasma; the UU, MH detection rate in 546 cases of sexual diseases positive were 44.13%, 7.88%, 0.55%, and, men＇s mycoplasma infection rate（28.63% ）was lower than that of women（71.36%）, so there existed significant difference （P〈0. 01） in the both. The results of drug sensitive test suggested the mycoplasma drug resistance had no relationship with the mycoplasma and HIV co infection, UU, MH and UU ＋ MHwere highly sensitive to josamycin and doxycycline, UU was highly resistant to spiramycin, ciprofloxacin, MH and UU ＋ MH were highly resistant to levofloxacin and spiramycin. Conclusion Mycoplasma treatment has no correlation with HIV infection, the mycoplasma infection is UU infection primarily, and UU ＋ MH mixed infection rate is also high. the first selection is josamycin and doxycycline in the treatment of genitourinary tract mycoplasma infection.