奥卡西平治疗癫部分性发作50例疗效观察

Observation of the curative effect of Oxcarbazepine in the treatment of partial seizures

目的观察奥卡西平治疗癫部分发作的疗效及安全性。方法 50例部分发作的癫患者采用奥卡西平治疗。成年患者的起始剂量为300mg/d。根据病情逐渐加量,3d后增至基本维持量600mg/d,仍有发作者继续加量,2周后达最佳效果或可耐受的最高剂量1 800mg/d;儿童患者起始剂量8～10mg/(kg.d),根据病情每周增加1次剂量,每次加量在10mg/(kg.d)以下,直至维持量30～40mg/(kg.d)。观察治疗后癫发作情况及药物不良反应。结果奥卡西平治疗5个月后,本组总有效率67.3%,完全控制率24.5%。用药1月内,本组10例患者出现不良反应,1例因剥脱性皮炎而停用此药。结论奥卡西平治疗癫部分性发作疗效较好,但有时可能产生严重的不良反应,临床应用时应谨慎。

Objective To observe the curative effect and the safety of Oxcarbazepine in the treatment of partial seizures.Methods Fifty patients with partial seizures were treated with Oxcarbazepine.The first dosage of adults was 300mg/d,and grew up with the progress of the disease.The dosage got normal stage（600mg/d）3days later if then still can not control the seizures.The dosage could keep growing until the best effect or the highest dosage（1 800mg/d）2weeks later.The first dosage of children was 8～10mg/（kg.d）,and grew up each week with the progress of disease.The increase of dosage each time was less than 10mg/（kg.d）,and the dosage could keep growing until the highest dosage 30～40mg/（kg.d）.The condition of seizures and the adverse reactions were observed.Results The total effective rate was 67.3%,and the perfect effective rate was 24.5%after the patients treated by Oxcarbazepine for 5months.The adverse reactions were appeared in 10cases during the first month of treatment,and then 1case stopped Oxcarbazepine because of systemic rash.Conclusion The curative efficacy of Oxcarbazepine on partial seizures is good,but sometimes,Oxcarbazepine may cause severe adverse reaction,so it must be used carefully.