替吉奥联合奥沙利铂治疗晚期胃癌的近期疗效观察

Recent efficacy of S-1 combined with oxaliplatin in treatment of advanced gastric cancer

目的观察替吉奥联合奥沙利铂治疗晚期胃癌的近期疗效和不良反应。方法选取36例晚期胃癌患者,替吉奥胶囊80 mg/m^2,分2次在早晚饭后半小时用水吞服,连续服用14天停7天,21天为1疗程。第1天奥沙利铂注射液130 m/m^2避光缓慢滴注2 h～4 h。连续治疗2个疗程后评价疗效。结果总有效率为52.8%(19/36),临床收益率为81.6%(29/36);主要不良反应为消化道反应、骨髓抑制,且多绝大多数为Ⅰ～Ⅱ度。结论替吉奥联合奥沙利铂治疗晚期胃癌近期疗效较好,不良反应可以耐受。

Objective To evaluate the recent efficacy and adverse effect of S - 1 combined with oxaliplatin in treatment of advanced gastric cancer. Methods 36 patients with advanced gastric cancer received S - 1 orally at a dose of 80mg/m^2 daily divided into 2 doses administered half an hour after breakfast and supper. The treatment lasted 14 days, followed 7 days interval. 130 mg/m^2 Oxaliplatin was intravenously injected for 2 -4 hours in the first day. The efficacy was evaluated after 2 cycles. Results The total response rate was 52.8% （19/36）and the clinical benefit response was 81.6% （29/36）. The major adverse effect were digestive toxic reactions and hemato- logical, and the great majority were I- Ⅱ grades. Conclusion S- 1 combined with oxaliplatin in treatment of advanced gastric cancer is effective, and the adverse effects are tolerable.