4’-苯氧基查尔酮类衍生物的合成

Synthesis of 4'-phenoxy Chalcone Derivatives

以联苯醚为起始原料,经傅克酰基化合成4-联苯醚乙酮,与苯甲醛衍生物以不同方式进行羟醛缩合反应,设计合成一系列4'-苯氧基查尔酮类衍生物。产物结构均经ESI-MS和1H NMR确认,合成了8种未见报道的4'-苯氧基查尔酮。

Choosing diphenyl ether as the starting material,1-（4-phenoxyphenyl）ethanone was abtained through the friedel-crafts reaction.After reacted with benzaldehyde derivatives in different ways,eight unreported 4＇-phenoxy chalcone derivatives were gained.The structures of all synthesized compounds were determined by 1H NMR and ESI-MS.