凝血和纤溶与缺血性心脏病的关系

Correlation between Ischemic Heart Disease and Coagulation and Fibrinolysis

纤维蛋白原为重要的凝血因子,越来越多的研究表明高纤维蛋白原水平导致高凝状态,诱发血管疾病造成缺血性损伤。纤溶酶原激活物抑制物1是血浆纤溶活性的主要决定因素。异常升高纤溶酶原激活物抑制物1阻碍纤维蛋白分解,从而增加血浆纤维蛋白原。高纤维蛋白原水平导致高凝状态促进血栓形成。纤溶酶原激活物抑制物参与多种代谢性疾病血栓前状态的形成,造成动脉血栓形成的危险性增加。纤溶酶原激活物抑制物1、纤维蛋白原不仅在冠心病的发病机制中发挥着重要作用,而且与冠心病患者的不良预后有关。

Fibrinogen are important clotting factors,more and more research shows that high fibrinogen level leads to high condensation state,induces vascular disease causing ischemic damage.The plasminogen activator inhibitor-1（PAI-1）is the main factor determining the plasma fibrinolytic activity.The elevated PAI-l impedes the decomposition of fibrin,and then results in the increased plasma fibrinogen.The high level of fibrinogen leads to the hypercoagulabale state and accelerates the thrombosis.PAI-1 is involved in the prethrombotic state formation of a variety of metabolic diseases,resulting in increased risk of arterial thrombosis.PAI-1 and fibrinogen not only play an important role in the pathogenensis of coronary heart disease,but is also related to the poor prognosis of the disease.