期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

动脉粥样硬化中的巨噬细胞分化 被引量：2

Macrophage Differentiation in Atherosclerosis
下载PDF
导出
摘要 动脉粥样硬化(AS)及相关心血管疾病已成为威胁人类死亡的主要原因之一,并将成为老龄化社会主要的卫生和社会经济问题。最近文献报道,AS的发生、发展与分化的不同巨噬细胞亚型相关。理解巨噬细胞增殖分化的分子机制、不同亚型巨噬细胞在AS过程中的功能,可能对寻找新的治疗方案,限制AS发展提供理论基础。 Atherosclerosis（AS）and associated cardiovascular disease have been one of the leading causes of mortality,and these disorders will be the main sanitary and socio-economic problem due to the progressive aging of our society.Recently,literatures reported that the progression of AS are associated with the presence of different macrophage subtypes.Understanding the molecular mechanisms that orchestrate macrophage differentiation and the precise role of distinct macrophage subsets might provide a basis for novel treatment strategies to limit the progression of AS.
作者 王海鸥 马兴义
机构地区 山东省定陶县人民医院急诊科
出处 《医学综述》 2012年第11期1642-1644,共3页 Medical Recapitulate
关键词 动脉粥样硬化 巨噬细胞分化 M1型巨噬细胞 M2型巨噬细胞 治疗前景 Atherosclerosis Macrophage differentiation M1 macrophages M2 macrophages Therapeutic potential
分类号 R365 [医药卫生—病理学] R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献22

  • 1Fuster JJ,Fernández P,González-Navarro H,et al.Control of cell proliferation in atherosclerosis:insights from animal models and hu-man studies[J].Cardiovasc Res,2010,86(2):254-264.
  • 2Yvan-Charvet L,Ranalletta M,Wang N,et al.Combined deficiency of ABCA1and ABCG1promotes foam cell accumulation and accel-erates atherosclerosis in mice[J].J Clin Invest,2007,117(12):3900-3908.
  • 3Hansson GK.Inflammation,atherosclerosis,and coronary artery dis-ease[J].N Engl J Med,2005,352(16):1685-1695.
  • 4Greaves DR,Gordon S.The macrophage scavenger receptor at30 years of age:current knowledge and future challenges[J].J Lipid Res,2009,50Suppl:S282-S286.
  • 5Gordon S,Martinez FO,Locati M,et al.Alternative activation of macrophages:mechanism and functions[J].Immunity,2010,32(5):593-604.
  • 6Gordon S,Gordon S,Locati M,et al.Alternative activation of mac-rophages[J].Nat Rev Immunol,2003,3(1):23-35.
  • 7Martinez FO,Gordon S,Locati M,et al.Transcriptional profiling of the human monocyte-to-macrophage differentiation and polariza-tion:new molecules and patterns of gene expression[J].J Immu-nol,2006,177(10):7303-1100.
  • 8Kadl A,Meher AK,Sharma PR,et al.Identification of a novel mac-rophage phenotype that develops in response to atherogenic phos-pholipids via Nrf2[J].Circ Res,2010,107(6):737-746.
  • 9Khallou-Laschet J,Varthaman A,Fornasa G,et al.Macrophage plasticity in experimental atherosclerosis[J].PLoS One,2010,5(1):e8852.
  • 10Hansson GK.Inflammation,atherosclerosis,and coronary artery dis-ease[J].N Engl J Med,2005,352(16):1685-1695.

同被引文献14

  • 1ALLAHVERDIAN S, PANNU PS, FRANCIS GA. Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation[ J ]. Cardiovasc Res ,2012,95 (2) : 165-172.
  • 2QI C, CAI Y, GUNN L , et al. Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived beta-glucans[ J]. Blood,2011,117 ( 25 ) :6825-6836.
  • 3GOODRIDGE HS,REYES CN, BECKER CA , et al. Activation of the innate immune receptor Dectin-1 upon formation of a "phagocytic synapse" [ J ]. Nature ,2011,472 ( 7344 ) :471-475.
  • 4ZHANG Y, WAHL LM. Synergistic enhancement of cytokine-induced human monoeyte matrix metalloproteinase-1 by C-reactive protein and oxidized LDL through differential regulation of monocyte chemotactie protein-1 and prostaglandin E2 [ J ]. J Leukoc Bio1,2006,79 ( 1 ) : 105-113.
  • 5WIGREN M,NILSSON J, KOLBUS D. Lymphocytes in atherosclerosis [J]. Cliu Chim Acta, 2012,413 (19-20) : 1562-1568.
  • 6ROVENSKY J, STANCIKOVA M, SVIK K, et al. The effects of beta-glucan isolated from pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis [ J ]. Rheumatol Int, 2011,31 (4) : 507-511.
  • 7KARUMUTHIL-MELETHIL S, PEREZ N, LI R, et al. Induction of innate immune response through TLR2 and dectin l prevents type 1 diabetes [ J ]. J Immunol, 2008,181 ( 12 ) : 8323-8334.
  • 8KAWASHIMA S, HIROSE K, IWATA A, et al. 13- glucan curdlan induces IL-10-producing CIM + T cells and inhibits allergic airway inflammation [ J ]. J Immunol,2012,189(12) :5713-5721.
  • 9CHANPUT W, REITSMA M, KLEINJANS L, et al. -glucans are involved in immune-modulation of THP-1 macrophages[ J ]. Mol Nutr Food Res,2012, 56(5) :822-833.
  • 10崔芬,杨志寅.血管内皮祖细胞与冠状动脉硬化性心脏病危险因素的研究现状[J].国际内科学杂志,2009,36(9):520-523. 被引量：5

引证文献2

二级引证文献5

医学综述
2012年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部