化肝汤1号治疗酒精性肝纤维化症状及肝功能改变

Symptoms and Liver Function Changes of Alcohol-Induced Liver Fibrosis Treated by Liver Soup 1

目的观察活血化瘀、软坚散结药配伍治疗肝纤维化时对患者主、次症状改变及肝功能的影响。方法将确诊为酒精性肝纤维化患者90例,随机分为三组,治疗组采用自制方剂化肝汤1号(醋鳖甲、黄芩、柴胡、赤芍等),对照组1采用凯西莱治疗,对照组2采用化肝汤1号和凯西莱联合治疗,疗程3个月。观察三组患者治疗前后主、次症状改善情况,血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、γ谷氨酰转肽酶(γ-GT)变化。结果三组治疗后的临床疗效比较差异无统计学意义(H=2.5897,P>0.05)。三组治疗后肝功能指标均有改善,与治疗前比较,差异有统计学意义(P<0.05)。结论化肝汤1号可有效地降低肝细胞的损害程度,促进受损细胞修复,从而改善肝功能。

Objective To observe the influence of traditional Chinese medicine combination of blood circulation promoting and stasis dissolving on the main and secondary symptoms and liver function in the treatment of liver fibrosis.Methods 90 patients with alcohol liver fibrosis were randomized into 3 groups,the treatment group was given the self-prescription of liver soup 1（vinegar turtle,skullcap,bupleurum root,red peony,etc.）,the control group 1 was given tiopronin and the control group 2 was given the self-prescription of liver soup 1 and tiopronin.After 3 months of treatment,improvement of the main symptoms and secondary symptoms,were observed,liver function were measured by AST,ALT and γ-GT before and after treatment.Results There was no significant difference in the clinical effect between the 3 groups（H=2.5897,P〉0.05）.The liver function indexes of the 3 groups all improved after treatment with statistical significance（P〈0.05）.Conclusion The liver soup 1 can effectively reduce the degree of liver cell damage and promote repair of damaged cells,thus improve the liver function.