不稳定型心绞痛伴焦虑患者超敏C反应蛋白、血小板参数变化及其临床意义

High Sensitive CReactive Protein,Platelet Parameter Changes and The Clinical Significance for Unstable Angina Patients with Anxiety

目的研究超敏C反应蛋白(hs-CRP)、血小板参数在不稳定型心绞痛(UAP)伴焦虑患者中的变化及其临床意义。方法选择经冠状动脉造影确诊为UAP的患者96例,通过Zung焦虑自评量表问卷调查分为轻度焦虑障碍组(50～70分)、重度障碍组(70分以上)和对照组(无焦虑)。应用放射免疫分析法检测患者血清中hs-CRP的水平,采集所有患者静脉血并用COULTER-750五分类血细胞分析仪检测血小板参数,并统计三组患者的年住院次数及年住院天数。结果三组患者hs-CRP、血小板平均体积(MPV)、血小板分布宽度比较差异有统计学意义(P<0.05)。三组患者年住院次数和年住院天数比较差异有统计学意义(P<0.05)。结论血清hs-CRP的浓度与UAP患者的焦虑相关,可作为临床UAP患者病情严重程度的参考指标。UAP患者随着焦虑的程度变化可能加速MPV增大和活化过程,其可能与冠状动脉血栓形成有关。

Objective To study the high sensitive C-reactive protein（hs-CRP）,platelet parameter changes in patients with unstable angina pectoris（UAP）accompanied by anxiety and its clinical significance.Methods 96 cases of UAP confirmed by coronary angiography were selected,and divided into mild anxiety disorder group（50-70 points）,severe disability group（over 70 points）and control group（no anxiety）by Zung Self-rating Anxiety Scale questionnaire.Radioimmunoassay detection was used to test serum hs-CRP levels,vein blood of all patients were collected,platelet parameters were tested with COULTER-750 five classification blood cell analyzer and the annual hospitalization time and length of the three groups were recorded.Results The differences of hs-CRP,average volume of blood platelet and mean platelet width in UAP were statistically significant（P〈0.05）.The difference of times in hospital and hospital stay was statistically significant（P〈0.05）.Conclusion Serum concentration of hs-CRP is related to the anxiety situation o UAP patients,which can be used as a clinical severity index of UAP patients.UAP patients with anxiety level changes might accelerate MPV increase and activation process,which may be associated with the formation of coronary artery thrombosis.