汕头大学医学院附属第一医院耐甲氧西林金黄色葡萄球菌(MRSA)耐药谱分析

Drug resistant spectrum of MRSA isolated from the First Affiliated Hospital of Shantou University Medical College

目的:了解汕头大学医学院附属第一医院分离的92株耐甲氧西林金黄色葡萄球菌(MRSA)的耐药情况。方法:琼脂稀释法测定17种抗菌药物对MRSA的最低抑菌浓度(MIC)。结果:92株MRSA对实验中所有β-内酰胺类抗生素的耐药率均在80%以上。绝大部分菌株对庆大霉素、红霉素、氟喹诺酮类也不敏感。超过半数的MRSA菌株对利福平保持敏感,对氯霉素、多西环素及米诺环素也普遍敏感,未发现耐万古霉素的MRSA菌株。结论:我院附属第一医院的MRSA呈多重耐药,但对氯霉素,半合成四环素及万古霉素仍然敏感。

Objective： To investigate the antibiotic resistance profiles of methicillin-resistant Staphylococcus aureus（MRSA） isola- ted from the first affiliated hospital of Shantou University Medical College. Method： The minimum inhibitory concentrations （MICs） of 17 antimicrobial agents against MRSA were tested by agar dilution method. Results： More than 80% of MRSA strains were resist- ant to all of the tested β-lactam antibiotics. Most of the strains were resistant to gentamycin, erythromycin and fluoroquinolones while more than half of MRSA strains were susceptible to rifampicin. Chloramphenicol, doxycycline and minocycline still remained a high activity against MRSA isolates. Vancomycin resistant Staphyleoccus aureus was not found in this study. Conclusion： Antimicrobial resistance of MRSA isolates in the First Affiliated Hospital, Shantou University Medical College are multidrug resistant. However, chloramphenicol, semisynthetic tetraeyclines and vancomyein are highly effective against MRSA isolates.