强化降脂对老年不稳定型心绞痛患者血小板-单核细胞活化的影响

Efficacy of Intensive Lipid-lowering Therapy on the Expression of Platelet and Monoytes CD42a+/CD14+ in elder Patients with Unstable Angina

目的观察强化降脂对氯吡格雷抑制老年不稳定型心绞痛患者血小板-单核细胞表达CD42a+/CD14+短期内的影响。方法将50例老年不稳定型心绞痛患者随机分成实验组25例(阿托伐他汀40mg)及对照组25例(阿托伐他汀20mg),检测比较服药前及服药后6小时和服药10天后血小板-单核细胞表达CD42a+/CD14+的变化。结果服药前两组CD42a+/CD14+分别为(9.43±2.53,10.12±2.26)%,服药后6小时降至(7.69±1.86,8.39±2.19)%,与服药前比较差异无统计学意义(P>O.05),组间比较差异无统计学意义(P>0.05);服药10天后降至(6.18±1.90,7.26±2.10)%,较服药前明显降低,差异有统计学意义(P<0.05),但两组比较差异无统计学意义(P>0.05)。结论老年不稳定型心绞痛患者服用较大剂量阿托伐他汀强化降脂并不抑制氯吡格雷短期内抗血小板-单核细胞活化作用。

Objective To investigate the effect of intensive lipid-lowering therapy on the expression of platelet and monoytes CD42a＋/CD14＋ in elder patients with unstable angina after clopidogrel intake.Methods Fifty patients with unstable angina were randomly divided into experimental group（atorvastatin 40mg,n=25） or control group（atorvastatin 20mg,n=25）.Samples of peripheral blood platelet and monocytes CD42a＋/CD14＋ were assayed at baseline,6 hours and 10 days after loading dose respectively.Results Platelet and monocytes CD42a＋/CD14＋ at baseline were（9.43±2.53,10.12±2.26）%,decreased to（7.69±1.86,8.39±2.19）% after taking the drugs at 6 hours,non-statistical to baseline（P〉0.05）,and decreased significantly（P〈0.05） to（6.18±1.90,7.26±2.10）% at 10 days.However,poor statistical differences were found between those two groups（P〉0.05）.Conclusions Atorvastatin with larger-dose do not inhibit the antiplatelet activity of clopidogrel in early period of combined therapy for elder unstable angina patients.