阿托伐他汀对不稳定型心绞痛病人血管内皮功能及血小板活化的影响

The Influence of Atorvastatin on Endothelial Function and Platelet Activation in Unstable Angina

目的探讨阿托伐他汀对不稳定型心绞痛病人血管内皮功能及血小板活化的影响。方法 68例不稳定型心绞痛病人随机分成常规组(34例)和阿托伐他汀组(34例)。所有病人分别于入院时及用药4周后取血,行血清一氧化氮(NO)、血浆内皮素-1(ET-1)及血小板胞质内α-颗粒膜糖蛋白(CD62p)测定。另选本院同期健康体检者30名作为对照组,要求采血前两周内未服用任何药物。结果不稳定型心绞痛病人血NO水平显著低于对照组(P<0.01),ET-1、CD62p水平明显高于对照组(P<0.01)。治疗4周后两组病人血清NO水平显著升高,血浆ET-1、血小板CD62水平明显降低(P<0.01),且治疗后两组之间有统计学意义(P<0.01),但治疗4周后两组患者血NO水平仍低于对照组(P<0.01),ET-1、CD62p水平仍高于对照组(P<0.01)。结论阿托伐他汀有改善不稳定型心绞痛病人内皮功能,抑制血小板活性作用,阿托伐他汀10mg/d治疗4周后不稳定型心绞痛病人仍然存在内皮功能障碍及血小板活化的问题。

Objective To evaluate effect of atorvastatin on endothelial function and the platelet activation in the patients with un- stable angina. Methods Sixty -eight patients with unstable angina were randomly divided into atorvastatin group （n=34） and routine therapy group （n= 34）. The platelet activation factor CD62p, serum nitric oxide（NO）, and plasma endothelin 1 （ET - 1） were measured before treatment and four weeks later after treatment respectively. Thirty healthy individuals were as the controls. Results The level of serum NO was lower while plasma ET - 1 and CD62p content were higher in the patients with unstable angina compared with control group （P〈0.01）. The levels of serum NO obviously increased,the levels of plasma ET - 1 and the platelet activation factor CD62p decreased after treatment （P〈0.01）. There was difference between the two groups （P〈0.01）. Conclusion The results suggested that atorvastatin could improve the endothelial function in patients with unstable angina, inhibit the platelet activity.