摘要
目的观察艾迪注射液联合FOLFOX4方案治疗晚期结直肠癌的疗效、毒副反应和对患者生活质量的影响。方法将74例晚期结直肠癌分为两组,治疗组应用艾迪注射液联合FOLFOX4方案化疗,对照组单用FOLFOX4方案化疗。治疗4周期前后对患者的疗效、毒副反应及生活质量进行评价。结果治疗组有效率为44.7%,对照组为38.9%,差异无显著性(P>0.05)。但是治疗组疾病控制率是78.9%,对照组是55.6%,差别有显著性(P<0.05)。治疗组血液毒副反应、胃肠道反应均明显低于对照组,差异均有显著性(P<0.05),且治疗组生活质量KPS评分高于对照组,差异有显著性(P<0.05)。结论艾迪注射液配合FOLFOX4方案治疗晚期结直肠癌可提高疾病控制率,减少化疗的毒副反应,改善患者的生活质量。
Objective To observe the efficacy, side effects and impact on the quality of life of Aidi injection combined with FOLFOX4 regimen in the treatment of advanced colorectal cancer patients. Methods Total of 74 patients were randomly divided into two groups: the trial group was treated with Aidi injection and FOLFOX4 while the control group was only administered FOLFOX4. After four courses of treatment, efficacy, quality of life and side effects were evalua- ted. Results The response rate in the trial group and the control group was 44.7% and 38. 9% re- spectively, without significant difference between the two groups(P〉0.05), but differences were signif- icant in the disease control rates. The incidence of adverse reactions in bone marrow and digestive tract was lower than that of control group (P〈0. 05),and the improvement in Karnofsky score in the trial group was higher than that in the control group(P〈0.05). Conclusion Aidi injection combined with FOLFOX4 is associated with reduced toxicity of chemotherapy, enhanced the disease control rate and im- proved quality of life of patients with advanced colorectal cancer.
出处
《青岛医药卫生》
2012年第3期173-174,共2页
Qingdao Medical Journal
关键词
艾迪注射液
化疗
晚期结直肠癌
Aidi injection
Chemotherapy
Advanced colorectal cancer