超声电导经皮治疗联合氟比洛芬酯在椎体后凸成形术后急性疼痛中的应用

Percutaneous iontophoresis combined with flurbiprofen axetil in the treatment of acute pain after percutaneous kyphoplasty

目的探讨超声电导经皮治疗联合氟比洛芬酯注射液在椎体后凸成形术后急性疼痛中的应用效果。方法选取2008年1月至2011年5月在我院行椎体后凸成形术后急性疼痛的患者60例,随机分为超声电导组(A组)、氟比洛芬酯组(B组)以及超声电导联合氟比洛芬酯组(C组)各20例。A组予以超声电导经皮治疗30min;B组予以氟比洛芬酯注射液静推50mg;C组予以超声电导经皮治疗联合氟比洛芬酯,方法同A、B组;均于术后急性疼痛6h内完成。对患者治疗前、治疗后的疼痛症状按视觉模拟评分法(VAS)进行评分及临床观察。结果 3组术后急性疼痛都得到不同程度的缓解。按VAS对3组患者进行评分,C组较A、B组改善更加明显(P<0.01);3组均未发生不良反应。结论超声电导靶向给药、氟比洛芬酯对椎体后凸成形术后急性疼痛都有效,但是二者联合应用的止痛效果更佳,疗效确切,值得临床应用推广。

Objective To observe the effects of percutaneous iontophoresis combined with flurbiprofen axetil in the treatment of acute pain after percutaneous kyphoplasty（PKP）. Methods From January 2008 to May 2011, 60 patients were selected after PKP, who were divided into percutaneous iontophoresis group （group A）, flurbiprofen axetil group （group B） and combination group （group C） randomly. Patients in group A were given the treatment of iontophoresis,30 minutes per time. Patients in group B were injected flurbiprofen axetil （50 mg） intravenously. Patients in group C were given the treatment of iontophoresis combined with flurbiprofen axetil 50 mg. All patients were assessed with visual analogue scale （VAS） and clinical observation before and after treatment in the three groups. Results After the treatment, All patients felt better than before in varied degrees, and the score of VAS in group C was better than that in group A and group B. No side effect or local irritation was found. Conclusions Percutaneous iontophoresis and fiurbiprofen axetil can release the acute pain of patients after PKP, but the effects of iontophoresis combined with flurbiprofen axetil in the treatment of acute pain after PKP are better. This therapy is very safe and valuable for widely use in clinic.