期刊文献+

6例丙戊酸钠脑病患者临床分析 被引量:4

下载PDF
导出
摘要 目的对丙戊酸钠脑病的临床特点和治疗进行分析总结。方法将6例丙戊酸钠脑病患者的临床表现、辅助检查及治疗进行回顾性分析。结果6例患者在接受丙戊酸钠治疗后出现意识障碍,血氨升高,不伴肝功能异常,脑电图为弥漫性慢波,减量或停用丙戊酸钠后症状缓解。结论丙戊酸钠脑病是丙戊酸钠少见但较为严重的并发症,需及时识别和治疗。
出处 《中国急救医学》 CAS CSCD 北大核心 2012年第6期568-570,共3页 Chinese Journal of Critical Care Medicine
  • 相关文献

参考文献8

  • 1ONeill M,Dubrey RW, Grocott- Mason RM. Valproate encepha- lopathy and hyperammonaemia[ J]. Postgrad Med J, 2002, 78 (919) : 316 -317.
  • 2Vivekanandan S, Nayak SD. Valproate - induced hyperammone- mic encephalopathy enhanced by topiramate and phenobarbitone: a case report and an update [ J ]. Ann Indian Acad Neurol, 2010, 13(2) : 145 -147.
  • 3Ziyeh S, Thiel T, Spreer J, et al. Valproate- induced encepha- lopathy: assessment with MR imaging and 1H MR spectroscopy [J]. Epilepsia, 2002, 43(9): 1101 -1105.
  • 4Gurjar M, Sinjhal S, Baronia AK, et al. Valproate - induced hy- perammonemic encephalopathy; A reminder of rare complication of valproate[ J]. J Emerg Trauma Shock, 2011 , 4(2) : 321 -322.
  • 5Carr RB Shrewsbuny K. Hyperammonemia due to valproic acid in the psychiatric setting [ J]. Am J Psychiatry, 2007, 164 ( 7 ) : 1020 - 1027.
  • 6Verrotti A, Trotta D, Morgese G, et al. Valproate - induced hy- perammonemic encephalopathy [ J ]. Metab Brain Dis, 2002, 17 (4) : 367 -373.
  • 7Deb SG, Samar B, Kartik S, etal. A case of non - hyperammone- mic valproate - induced encephalopathy [ J ]. Neurol Asia, 2006, 11(4): 135-137.
  • 8Eyer F, Felgenhauer N, Gempel K, et al. Acute valproate poison- ing: pharmacokinetics, alteration in fatty ac'id metabolism, and changes during therapy [ J]. J Clin Psychopharmaeol, 2005, 25 (4) : 376 -380.

同被引文献49

  • 1李国良,肖波.丙戊酸钠脑病[J].国外医学(神经病学.神经外科学分册),2004,31(3):266-269. 被引量:9
  • 2Agarwal R, Sharma S, Chhillar N, et al. Hyperammonemia andhepatic status during valproate therapy[J]. Indian Journal ofClinical Biochemistry,2009,24(4):366-369.
  • 3Topczewski A, Caboclo LOSF. Valproate-induced acuteencephalopathy[J]. Einstein,2008,6( 1):86-87.
  • 4Lewis C, Deshpande A, Tesar GE, et al. Valproate-inducedhyperammonemic encephalopathy: a brief reviewfj]. Curr MedRes Opin,2012,28(6):1039-1042.
  • 5Lheureux PE, Hantson P. Carnitine in the treatment of valproicacid-induced toxicity[J]. Clin Toxicol (Phila),2009,47(2):101-111.
  • 6Perucca E. Pharmacological and therapeutic properties ofvalproate: a summary after 35 years of clinical experience[J].CNS Drugs,2002,16(10):695-714.
  • 7Konig SA, Schenk M, Sick C, et al. Fatal liver failure associatedwith valproate therapy in a patient with Friedreich、disease:review of valproate hepatotoxicity in adults[J]. Epilepsia, 1999,40(7):1036-1040.
  • 8Asconape JJ, Penry JK, Dreifuss FE, et al. Valproate-associatedpancreatitis[J]. Epilepsia, 1993,34(1): 177-183.
  • 9Ghosh VB, Kapoor S, Prakash A, et al. Cerebellar atrophy in achild with valproate toxicity[J]. Indian J Pediatr,2011,78(8):999-1001.
  • 10Rupasinghe J, Jasinarachchi M. Progressive encephalopathywith cerebral oedema and infarctions associated with valproateand diazepam overdose[J]. J Clin Neurosci,2011,18(5):710-711.

引证文献4

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部