首发精神分裂症先证者未患病父母额叶白质和海马氢质子波谱研究

Proton magnetic resonance spectroscopy of the frontal lobe and hippocampus in unaffected parents of schizophrenia probands

目的探讨首发精神分裂症患者未患病父母额叶白质、海马氢质子磁共振质子波谱（^1H-MRS）变化特点。方法对首发精神分裂症患者未患病父亲19例、男性正常对照19例、未患病母亲24例、女性正常对照24例进行氢质子波谱扫描，检测双侧额叶白质和海马的N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr），以Cr为参照物，分别计算双侧NAA／Cr、Cho／Cr比值。采用配对t检验、独立样本t检验进行统计分析。结果未患病母亲组双侧额叶白质Cho／Cr[左侧（1．10±0．13），右侧（1．08±0．12）]均高于女性正常对照组[左侧（1．03±0．10），右侧（1．02±0．09）]，差异有统计学意义（t=2．21，2．23，P〈0．05）。女性正常对照组左侧额叶NAA／Cr（1．64±0．12）比右侧额叶（1．74±0．13）低，差异有统计学意义（t=3．16，P=0．004），而未患病母亲组前额白质左右侧NAA／Cr差异无统计学意义（P〉0．05）。未患病父亲组额叶白质、海马双侧NAA／Cr和Cho／Cr与男性正常对照相比差异无统计学意义（P〉0．05）。结论未患病母亲组额叶白质存有代谢物水平异常和NAA／Cr非对称性的消失。

Objective To examine biochemical characteristics of the frontal lobe and hippocampus in un- affected parents of schizophrenia probands using proton magnetic resonance spectroscopy （1H-MRS）. Method 19 unaffected fathers of schizophrenia probands with matched 19 male healthy control subjects and 24 unaffected mothers of schizophrenia probands with matched 24 female healthy control subjects were included in the study. 1H-MRS was performed in two sides of the hippoeampus and frontal lobes regions. The ratios of N-Acetylaspartate （NAA）, choline （Cho）to creatine （Cr） were measured . One-sample T test and paired-samples t test were used for statistic process. Results Unaffected mothers of schizophrenia probands had a higher Cho/Cr ratio （left （1.10 ±0.13 ,right（ 1.08 ±0.12） ） in the frontal white matter compared with matched female health control sub- jects（ left（ 1.03 ± 0. 10 ）, fight （ 1.02 ± 0.09 ） ）. The NAA/Cr ratio was significantly reduced in the left frontal white matter of female health control subjects compared to right（ 1.64 ± 0.12 vs 1.74 ± 0.13 ） ,but this difference was not observed in unaffected mothers of schizophrenia probands. There were no significant differences in metabolites for frontal lobe and hippocampus regions between unaffected fathers of schizophrenia probands and male healthy control subjects groups（ all P 〉 0.05 ）. Conclusion The results implicate that the metabolic abnormalities and disappeared asymmetry of NAA/Cr might exist in the frontal white matter among unaffected mothers of schizophrenia probands.