血压对自发性高血压大鼠脑出血后血肿周围水肿的影响

Effect of blood pressure on perihematomal edenm following intracerebral hemorrhage in spontaneously hypertensive rats

目的探讨自发性高血压大鼠（spontaneous hypertensive rat，SHR）脑出血后血肿与血肿周围水肿变化以及血压与血肿周围水肿的相关性。方法24只6月龄雄性SHR，随机分为脑出血1、3、5和7嘲（每组6只）。尾袖法测定血压，Ⅳ型胶原酶注入尾壳核建立脑出血模型，磁共振T，加权成像观察血肿、血肿周围水肿。结果模型制作后ld时的血压较模型制作前显著降低，3d起血压逐渐升高。平行轮廓检验显示，血压变化率与血肿周围水肿体积变化率之间的总体轮廓相互平行（F：2．820，P=0．063），重合轮廓检验显示，两者总体轮廓不重合（F：10．961，P=0．000），即血肿周围水肿体积变化率与血压变化率趋势一致。收缩压变化率与血肿周围水肿体积变化率（r=0．527，P=0．024）和血肿体积变化率（r=0．755，P=0．000）均呈显著正相关。结论SHR脑出血当天脑水肿即出现并迅速扩大，3d时达峰值，此后逐渐消退。脑出血后1d时血压显著下降，3d起开始逐渐升高，直至7d。血压与血肿周围水肿体积的变化趋势相互平行，收缩压变化率与血肿周围水肿体积变化率呈正相关。

Objective To investigate the changes of hematoma and perihematomal edema in spontaneous hypertensive rats （SHRs）, as well as the correlation between blood pressures and perihematomal edema. Methods A total of 24 ＆month-old male SHRs were included. They were randomly divided into intracerebral hemorrhage 1-, 3-, 5-, and 7-day groups （n =6 in each group）. Blood pressure was determined by tail-cuff sphyffnomanometry. Collagenase IV was injected into caudate nucleus in order to induce a model of intracerebral hemorrhage. Magnetic resonance T2 weighted imaging was used to observe hematoma and perihematornal edema. Results On day 1 after modeling, the blood pressure was decreased significantly compared to that before modeling, and it was elevated graduaLly on day 3. Parallel profile test showed that the overall profile was parallel between the change rate of blood pressure and the change rate of perihematomal edema volume （F =2. 820, P = 0. 063）. The coincident profile test showed that both the overall profiles did not coincide （F = 10. 961, P = 0. 000）. The change rate of systolic blood pressure was significantly positively correlated with the ehange rate of perihematomal edema volume （r =0. 527, P =0. 024） and the change rate of penrihcmatomal edema volume （r = 0. 755, P = 0. 000） showed a significant positive correlation. Conclusions Brain edema appeared and expanded rapidly on the day of intracerebral hemorrhage in SHRs. It reached the peak on day 3, and then dissipated gradually. The blood pressure decreased significantly on day 1 after intrace^bral hemorrhage, and it began to increase from day 3 till day 7. The changing trends of the blood pressure and perihcmatomal edema volume wereparallel to each other, and the change rate of systolic blood pressure and the change rate of perihematomal edema volume showed a positive correlation.