STIM1／Orai1可能是防治缺血性脑血管病的新靶点

STlM1/Orail may be a new target for the prevention and treatlnent of ischendc cerebrovascular disease

近年来，通过RNA干扰技术在果蝇细胞中鉴定出钙离子释放激活钙通道（Ca^2＋ release—activated calcium channel，CRAC）的2种重要组成蛋白，即位于内质网上的Ca^2＋感受器问质相互作用分子1（stromal interaction molecule1，STIMl）和位于细胞膜上的CRAC通道蛋白0rail。研究表明，STIM1和Orai1对血管平滑肌细胞、血小板、血管内皮细胞等多种细胞均有调控作用，在血管平滑肌细胞表型转化、止血、血栓形成、新生血管发生等方面发挥着重要作用，显示两者可能与缺血性脑血管病密切相关。文章就STIM1和Orai1蛋白在缺血性脑血管病方面的研究进展进行了综述，以探讨STIM1和Orai1作为防治缺血性脑血管病的新靶点的可能性。

In recent years, two important component proteins of the calcium release-activated calcium channel （CRAC） were identified from Drosophila cells by RNA interference technique, including the calcium sensor stromal interaction molecule 1 （STIM1） on the endoplasmic reticulum and the CRAC channel protein Omil on the cell membrane. Studies have shown that STIM1 and Orail have regulatory effects on vascular smooth muscle cells, platelets, vascular endothelial cells and other cells. They play important roles in the aspects of vascular smooth muscle cell phenotypic modulation, hemostasis, thrombosis, and neovascularization. It shows that they both may be closely associated with ischemic cerebrovascular disease. This article reviews the advances in research on STIM 1 and Oral1 proteins in ischemic cerebrovascular disease in order to investigate the possibility of STIM1/Orail as a new target in the prevention and treatment of ischemic cerebrovascular disease.