阳离子交换树脂SAC 001×7对阿卡波糖的吸附性能研究

Study on Acarbose Adsorption Performance of Cation Exchanger SAC 001×7

研究了水相中阳离子交换树脂SAC001×7对阿卡波糖的吸附平衡、吸附热力学及吸附动力学,探讨了运用SAC001×7从发酵液中分离阿卡波糖的可行性。吸附平衡实验表明,SAC001×7吸附阿卡波糖的最大平衡吸附容量在研究范围内随温度升高而增大,在313 K时达到951.5 mg g 1,且吸附等温线符合Langmuir模型。计算了阿卡波糖吸附热力学函数,ΔG<0,ΔS>0,ΔH>0,表明SAC001×7吸附阿卡波糖是一个吸热过程,升高温度促进吸附。吸附动力学实验表明,90%以上的阿卡波糖吸附发生在前40 min以内,120 min达到吸附平衡,阿卡波糖交换速率受颗粒内扩散限制。在考察浓度范围内,内扩散速率常数随阿卡波糖初始浓度增大而增大,受温度的影响较小。

In order to investigate the feasibility of using the cation exchanger resin SAC 001 x7 to separate acarbose from its fermentation broth by adsorption, the adsorption equilibrium, thermodynamic and kinetics of adsorbing acarbose in aqueous phase by resin SAC 001x7 were studied. Batch equilibrium experiments demonstrate that, in the examined temperature range, the equilibrium adsorption capacity of the SAC 001 x7 increases with the increase of adsorption temperature and reaches its maximum value of 951.5 mg.g-1 at 313 K. Based on the analysis of the adsorbing isotherms, the adsorption data of adsorbing acarbose on SAC 001 x7 fit the Langmuir equation well. The thermodynamic parameters fitting reveals that AG〈0, AS〉0, AH〉0, it indicates that the acarbose adsorption is endothermic and raising the adsorption temperature will favor the adsorption process. The adsorption kinetics show that more than 90% of acarbose adsorption occurs within 40 min and the adsorption will complete in 120 min. Moreover, among the kinetic models applied, the intraparticle diffusion model may explain the acarbose adsorption most suitably. The intraparaticle diffusion rate constant increases with the increase of initial acarbose concentration, and is insignificantly influenced by the temperature.