摘要
采用在体电活动记录方法，观察ＤＤＰＨ［１－（２，６－二甲基苯氧基）－２－（３，４－二甲氧基苯乙氨基）丙烷盐酸盐〕对兔输尿管平滑肌电活动影响。结果表明； ＤＤＰＨ ８ ｍｇ／ｋｇ静脉给药后 ４５ ｍｉｎ，输尿管平滑肌电活动频率开始显著减慢（Ｐ＜０．０５），而 １６ ｍｇ／ｋｇ给药后 １ｍｉｎ即开始显著减慢（Ｐ＜０．０５），且持续 ２ ｈ以上。提示，ＤＤＰＨ可对兔输尿管平滑肌电活动产生一定的负性影响。
By using in vivo electrical activity recording, the effects of DDPH [1-(2, 6- dimethylphenoxy)-2- (3, 4-dimethoxy phenylethylamino) propane hydrochloride]on the frequency of electrical activity in ureteral smooth muscle of rabbits were studied. DDPH 8 mg/kg can decrease the frequency of electrical activity 45 min after intravenous administrationn (P<0. 05); 16 mg/kg,the frequency lower immediately and last more than 2 h (P<0. 05). The results suggested that DDPH produce negative effects on rabbit smooth musculature of the ureter.
出处
《同济医科大学学报》
CSCD
2000年第1期59-61,共3页
Acta Universitatis Medicinae Tongji
基金
国家医药管理局资助!(No.CDN-87040)
关键词
尼莫地平
酚妥拉明
输尿管平滑肌
降压药
DDPH
antihypertensive agents
phentolamine
Nimodipine
ureteral smooth muscle
electrical activity
