静息态与任务态功能MRI在脑肿瘤患者术前运动皮层定位的研究

Comparative study on localization of motor cortex of patients with brain tumors by rs-fMRI and task-based fMRI

目的通过对比脑肿瘤患者的静息态功能MRI(rs-fMRI)与任务态功能MRI(task-fMRI),评价rs-fMRI在脑肿瘤患者运动皮层术前定位中的作用。方法对12例脑肿瘤患者行fMRI,所有数据均采用FSL软件多元线性优化分解的独立成分(MELODIC ICA)分析方法。结果实验结果表明肿瘤越靠近大脑中央沟附近(例1、3、7、8、11患者),rs-fMRI和task-based fMRI的激活差异较大;而病灶远离大脑中央沟(例2、4、5、6、9、10、12患者),rs-fMRI和task-based fMRI叠加图像比较相符;患侧激活较健侧激活有所减弱。结论 rs-fMRI及task-based fMRI可以作为脑肿瘤患者运动区术前定位的一种辅助方法,且rs-fMRI尚不能替代task-based fMRI而作为一种单独的术前定位运动皮层的方法。

Objective： To evaluate whether rs-fMRI is appropriate and robust for mapping motor cortex in presurgical planning, by comparing the rs-fMRl and task- based IMRI in mapping motor cortex of brain tumors. Materials and Methods： Twelve patients with brain tumors were selected. Their fMRI dataset was analyzed by FMRIB Software Library Multivariate Exploratory Linear Optimized Decomposition into Independent Components （FSL MELODIC ICA） software （www.fmrib.ox.ac.uk/ fsl）. Results： The experimental results showed that the motor activation mappings from rs-fMRI are quite similar to those the task-based fMRl in the patients with tumors far from motor cortex activation （patient 1, 3, 7, 8, 11）. However, in each of the patients with tumor around motor cortex （patient 2, 4, 5, 6, 9, 10, 12）, the spatial distribution of motor cortex activation from the rs-fMR1 does not match the distribution from the task-based fMRI well. Conclusion： Based on our experimental results, we find that the combination of rs-fMRl and task-based fMRl should be treated as a complementary approach to assessing the sensorimotor area in patients with brain tumors, which cannot be performed by rs-fMRl alone.