局灶性脑皮质发育不良的MRI检查与诊断

Status of MR imaging for focal cortical dysplasia

局灶性皮质发育不良(focal cortical dysplasia,FCD)的特点是局部皮质分层紊乱,出现异常神经元和胶质细胞。FCD是药物难治性癫痫的常见原因。随着MRI技术的发展,FCD的发现率逐渐提高。MRI能显示FCD的位置、大小及累及范围,主要表现为局限性皮质增厚、灰白质分界模糊及皮层下白质信号改变。作者就MRI检查技术及表现在FCD的研究进展进行综述。

Focal cortical dysplasia （FCD） is characterized by the dyslamination and the presence of abnormal neurons and glia arranged abnormally in focal areas of the cerebral. FCD is a common cause of pharmaco-resistant epilepsy. With the recent progress in magnetic resonance imaging （MRI）, FCD are being identified increasingly. MRI can show the topographical characterization of the lesion with respect to its location, size and extension. FCD exhibits a variety of features： local cortical thickening, blurring of the grey-matter to white-matter surface, signal changes in the underlying white matter. The research and current status of MRI on FCD were reviewed in this article.