摘要
目的从细胞因子水平探讨幽门螺杆菌(HP)对慢性活动性胃炎发生发展的作用及其临床意义。方法收集91例慢性活动性胃炎患者,其中轻-中度慢性活动性胃炎患者51例,重度慢性活动性胃炎患者40例和健康对照者40例,采用ELISA法检测以上三组患者外周血中IL-6、TGF-β1及IL-17的浓度,并分析其与HP感染的关系。结果慢性活动性胃炎轻-中度组IL-6的浓度与对照组无统计学差异;TGF-β1、IL-17的浓度显著高于对照组(P<0.01)。重度组三种细胞因子的浓度均显著高于轻-中度组和对照组(P<0.01)。HP阳性患者IL-6、TGF-β1、IL-17的浓度均高于阴性患者(P<0.01)。结论细胞因子IL-6、TGF-β1及IL-17参与慢性活动性胃炎的发生发展;HP感染对炎症的发生发展有促进作用,通过检测上述细胞因子为临床评价治疗效果、判断预后以及进行免疫治疗提供一定的理论依据。
Objective From the level of cytokines,analyze the affection of helicobacter pylori in chronic active gastritis development and its clinical significance.Methods 91 cases of chronic active gastritis patients（51 patients with mild-moderate chronic active gastritis,40 patients with severe chronic active gastritis,and 40 healthy controls）were detected by ELISA with peripheral blood IL-6,TGF-β1 and IL-17 concentrations,and analyzed its relationship with helicobacter pylori infection.Results Compared with the control group,IL-6 concentration of mild-moderate group showed no significant difference.The TGF-β1 and IL-17 concentration of mild-moderate group was significantly higher than the control group（P0.01）.The concentration of three cytokines in severe group were significantly higher than the mild-moderate group and the control group（P0.01）.The IL-6,TGF-β1 and IL-17 concentration in the positive group of helicobacter pylori infection patients were significantly higher than negative group（P0.01）.Conclusions Cytokines IL-6,TGF-β1 and IL-17 participate in the incidence of chronic active gastritis development.Helicobacter pylori infection could promote the development of inflammation.By detecting these cytokines can provide a theoretical basis for clinical evaluation of treatment,prognosis,and immunotherapy.
出处
《中华临床医师杂志（电子版）》
CAS
2012年第11期50-52,共3页
Chinese Journal of Clinicians(Electronic Edition)
