摘要
目的 探讨系统性红斑狼疮(SLE) 患者中Th2 型细胞因子m RNA 的表达。方法 用逆转录多聚酶链反应( RTPCR) 法检测了10 例正常人和15 例活动期SLE 患者外周血单个核细胞(PBMC) 中白介素6(IL6) 和白介素10(IL10) m RNA 表达的水平。结果 与正常人相比,活动期SLE 患者PBMC 中IL6 和IL10 m RNA 的表达水平均增高( 均 P< 0 .01) 。结论 SLE 患者中Th2 型细胞因子IL6 IL10 的表达上调,可能在发病机制中起一定作用。
Objective To investigate the mRNA expression of Th2 type cytokines in SLE patients.Methods Applying RT PCR technique to semiquantitatively analyse the mRNA expression of IL 6 and IL 10 in the PBMCs from 10 normal controls and 15 SLE patients.Results Compared with normal controls,the mRNA expression of IL 6 and IL 10 in SLE PBMCs was significantly increased( P <0.01,both).Conclusion The Th2 type cytokine IL 6 IL 10 expression in active SLE patients is up regulated,which might play some roles in the pathogenesis of SLE.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2000年第1期4-5,共2页
The Chinese Journal of Dermatovenereology
基金
高等院校博士学科点专项科研基金!资助课题9502084