Fas FasL在Bowen病和鳞状细胞癌中的表达及意义

Expression of Fas and Fas Ligand in Bowen's Disease and Squamous Cell Carcinoma.

目的 探讨由Ｆａｓ 和ＦａｓＬ 介导的凋亡在Ｂｏｗｅｎ 病和鳞状细胞癌（ＳＣＣ） 局部免疫反应中的作用。方法 采用免疫组化对Ｂｏｗｅｎ 病、ＳＣＣ 不同恶性度分级的皮损蜡块组织中Ｆａｓ 、ＦａｓＬ 表达情况进行检测。结果 Ｆａｓ 、ＦａｓＬ 在Ｂｏ ｗｅｎ 病和ＳＣＣ 上均表达，但随肿瘤恶性程度升高Ｆａｓ 表达逐渐减弱，而ＦａｓＬ 表达逐渐增强。结论 由Ｆａｓ 系统介导的凋亡所引发的异常免疫杀伤作用可能参于某些表皮肿瘤局部免疫逃避机制，从而与肿瘤良恶性分级、预后有一定关系。

Objective To study the function of apoptosis mediated by Fas and Fas ligand in Bowen's disease and sqamous cell carcoma(SCC).Method The immunohistochemistry was empolyed to show the expression of Fas and Fas ligand in Bowen's Disease and SCC.Results The positive rates of Fas and Fas ligand in Bowen's Disease and SCC were both 100%,the intense of expressions of Fas was downregulated and that of Fas ligand was upregulated along with the increasing malignant degree of tumors.Conclusions Expression of Fas and Fas ligand are related to degree of epidermal tumors,and apoptosis mediated by Fas and Fas ligand may be one cause responsible to epidermal tumor's local immune evasion.