摘要
目的 探讨由Fas 和FasL 介导的凋亡在Bowen 病和鳞状细胞癌(SCC) 局部免疫反应中的作用。方法 采用免疫组化对Bowen 病、SCC 不同恶性度分级的皮损蜡块组织中Fas 、FasL 表达情况进行检测。结果 Fas 、FasL 在Bo wen 病和SCC 上均表达,但随肿瘤恶性程度升高Fas 表达逐渐减弱,而FasL 表达逐渐增强。结论 由Fas 系统介导的凋亡所引发的异常免疫杀伤作用可能参于某些表皮肿瘤局部免疫逃避机制,从而与肿瘤良恶性分级、预后有一定关系。
Objective To study the function of apoptosis mediated by Fas and Fas ligand in Bowen's disease and sqamous cell carcoma(SCC).Method The immunohistochemistry was empolyed to show the expression of Fas and Fas ligand in Bowen's Disease and SCC.Results The positive rates of Fas and Fas ligand in Bowen's Disease and SCC were both 100%,the intense of expressions of Fas was downregulated and that of Fas ligand was upregulated along with the increasing malignant degree of tumors.Conclusions Expression of Fas and Fas ligand are related to degree of epidermal tumors,and apoptosis mediated by Fas and Fas ligand may be one cause responsible to epidermal tumor's local immune evasion.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2000年第1期10-12,共3页
The Chinese Journal of Dermatovenereology