顺爽滋养去屑型洗发露CHL细胞体外染色体畸变试验

Effects of shunshuang nourishing anti-dandruff shampoo on chromosome aberration of CHL cell in vitro

目的:检测顺爽滋养去屑型洗发露对CHL细胞染色体致畸变作用。方法:用体外方法检测顺爽洗发露在0.5 mg/ml、0.25 mg/ml、0.125 mg/ml时,代谢活化组(含S9mix)及非活化组(不含S9mix)CHL细胞的染色体畸变率。结果:顺爽洗发露代谢活化组(含S9mix)及非活化组(不含S9mix)的染色体畸变率均低于5%。结论:在本实验条件下顺爽滋养去屑型洗发露未诱发CHL细胞染色体畸变率增加。

Objective：To assess whether shunshuang nourishing anti-dandruff shampoo causes the chromosome aberration.Methods：At the concentrations of 0.5 mg/ml,0.25 mg/ml,0.125 mg/ml,the mutagenicity of shunshuang nourishing anti-dandruff shampoo on Chinese hamster lung cell in the presence and absence of the liver homogenate fraction（S9mix） in vitro was evaluated.Results：Shunshuang shampoo achieved a chromosome aberration of less than 5% in the presence and absence of S9mix.Conclusion：Shunshuang nourishing anti-dandruff shampoo has not demonstrated effects on chromosome aberration.