2/100Hz跨皮肤电刺激对男性海洛因成瘾者性机能障碍及血清性激素水平的影响

Effect of 2/100 Hz Transcutaneous Electrical Nerve Stimulation on Sexual Dysfunction and Serum Sex Hormone of Heroin Addicts

目的 :评价韩氏戒毒仪 (简称韩氏仪 ,HANS) 2 / 10 0Hz电刺激对海洛因导致的性机能障碍的治疗作用。方法 :33例志愿受试者被随机分到丁丙诺啡组 (简称BPN组 ;n =16 )或HANS加小剂量BPN组(简称HANS组 ;n =17) ,两组所用的BPN剂量以患者不出现戒断症状为标准。HANS的频率是 2Hz和10 0Hz ,两种频率每隔 3s自动切换。HANS组患者接受电刺激的 8个穴位分别是一侧上肢合谷和劳宫 ,对侧上肢内关和外关 ,两侧下肢行间和三阴交 ,每次刺激 30min ,前 2周每日 3～ 4次 ,后 2周每日 1～ 2次。结果 :(1) 14日以后患者尿样吗啡分析呈阴性。 (2 )性机能问询调查 (视觉模拟尺评分 )结果显示 :HANS组治疗 2周后性机能总分较治疗前升高了 10 2 % (P <0 0 1) ;与单纯BPN组治疗后同期相比 ,增高 10 7% (P <0 0 1)。 (3)HANS组治疗 4周后血清黄体生成素 (LH)较治疗前增高 137% (P <0 0 5) ;睾酮 (T)水平升高118% (P <0 0 5) ;HANS组治疗 4周后血浆睾酮水平较单纯PBN组治疗后同期高出 79 6 % (P <0 0 5)。结论 :HANS的 2 / 10 0Hz跨皮肤电刺激可促使海洛因成瘾者性机能恢复 ,血清性激素LH和T水平显著上升。

Objective: To evaluate the effect of 2/100 Hz electrical stimulation produced by Han′s acupoint nerve stimulator (HANS) in treating heroin induced sex dysfunction. Methods: Thirty three heroin addicts were randomly divided into 2 groups to receive either buprenorphine (BPN group, n=16) or HANS plus small dose of BPN (HANS group, n=17) for 14 days. The doses of BPN were tailored according to individual requirement that could totally abolish withdrawal syndrome. The frequency of HANS was 2Hz and 100 Hz shifting automatically, each lasting for 3 seconds. The stimulation was applied to 8 acupoints, the Hegu and Laogong of one upper limb, Neiguan and Waiguan of another limb, Sanyinjiao and Xingjian of both lower limbs, for 30 min. The therapy was carried out 3-4 times per day in the initial two weeks of treatment, and reduced to 1-2 times per day in the following 2 weeks. Results: (1) The urine analysis for morphine in both groups turned to negative 14 days after treatment. (2) After 2 weeks of treatment, the composite score (Visual Analog Scale, VAS) of sexual function in HANS group showed a 102% increase (P<0 01) compared with before treatment and was 107% of that in the BPN group (P<0 01). (3) After 4 weeks treatment the serum concentration of luteinizing hormone (LH) and testosterone (T) in the HANS group showed a 137% and 118% increase respectively compared with those before treatment (P<0 05), and the level of LH was 79.6% of that in the BPN group (P<0 05). Conclusion: The 2/100 Hz transcutaneous electrical stimulation produced by Han′s acupoint nerve stimulator could improve the recovery of sexual function and raise the serum concentration of LH and T in heroin addicts.