高危骨髓增生异常综合征的治疗和分析

Analysis and treatment of patients with highrisk myelodysplastic syndrome

目的探讨高危骨髓增生异常综合征(MDS)的临床特点和实验研究,观察联合化疗对高危MDS的疗效,对治疗效果进行分析。方法应用联合化疗方案对31例高危MDS患者进行治疗,结合实验室检查结果分析其疗效。结果 31例高危MDS患者,化疗后完全缓解12例(38.7%),该12例患者中位生存期为18个月。19例未缓解者中位生存期为7个月。化疗主要不良反应为骨髓抑制期感染,少数出现肝功能异常和心肌损害。结论联合化疗对高危MDS患者有一定疗效,需加强对症支持治疗。

Objective To study the clinical characteristics and laboratory results of patients with high risk myelodysplastic syndrome（MDS）.The curative effects of common chemotherapy on patients were observed.Methods Common chemotherapy was used in 31 cases of high risk MDS,and based on the lab results,the curative effects on the patients were analyzed.Results Among the 31 cases of high risk MDS,after treated with common therapy,12 cases（38.7%） got complete remission（CR）.Midian survival time was 18 months of the 12 cases.Midian survival time was 7 months of the 19 NR cases.The main side effects of chemotherapy included infection in bone marrow inhibition period.A few cases had liver funtion abnormality or myocardial damage.Conclusion Common chemotherapy is effective to treat high risk MDS,and symptomatic supportive treatment should be strengthened.