ABO血型与原发性肝癌及人体免疫功能的相关性探讨

Study on the correlation between ABO blood groups and the occurrence of primary hepatocellular carcinoma and the influence on immune state

目的:探讨青岛地区ABO血型与原发性肝癌的相关性及其对T细胞亚群比例的影响。方法:应用流式细胞仪检测健康对照组340例、原发性肝癌患者140例外周血中的T淋巴细胞亚群并进行分析比较。结果:原发性肝癌患者中,B型血患该病比例较其他血型患者高,且B型血患者的T细胞亚群变化较正常B型血人群显著。A型血患者比例明显降低。结论:青岛地区B型血人群更易发生原发性肝癌,也更易出现细胞免疫功能的紊乱,而A型血可能是原发性肝癌的保护性因素。

Objective：To investigate the correlation between ABO blood groups,and the changes of T cell subset by different ABO blood group in local.Methods：The peripheral blood were collected from 340 healthy people and 140 primary hepatocellular carcinoma patients.The population of T cell subset was evaluated by flow cytometry,and compare with healthy people.Results：Contrast with other blood groups,the proportion of B types PHC patient increased rapidly,and T cell subset appeared remarkable change.Conclusion：B blood stye was a risk factor of PHC,and more prone to significant changes than other blood groups in local;while blood group A seems to be unsusceptible to PHC.