女性激素水平与围绝经期抑郁的关系探讨

目的探讨围绝经期抑郁患者激素水平与抑郁的相关性。方法分别对87例围绝经期抑郁患者,87例健康围绝经期妇女以及健康育龄期妇女检测其血清雌二醇(E2)和孕酮(P)水平。结果抑郁组E2和健康围绝经期组比较无差异,无统计学意义(P>0.05);但与生育期妇女比较有显著性差异(P<0.01)。P检测结果与围绝经期对照组比较有差异(P<0.05),与生育期对照组有显著差异(P<0.01),E2/P比值与围绝经期比较有显著差异(P<0.01);HAMD评定结果与E2/P比值呈负相关。结论围绝经期抑郁者体内激素水平相对其他患者体内激素水平比例失调;说明E2和P激素调节功能紊乱与围绝经期抑郁有重要意义。

Objective To investigate the correlation between perimenopause depression disorder and female hormone levels. Methods 87peri menopausal women with depression disorder were assessed and 87 peri menopause ones without depression served as controls. Determination was adopted to determine the serum E2 and P levels. Re- sult Levels of E2 had no significant difference between the two groups （ P 〉 0.05 ）. , but had significant difference compared with the growth period women group（ P 〈 0.01 ） ,the ratio of E2/P was statistically decreased in the de- pression group in contrast to the control group（P 〈0.01 ） ;A positive correlation was found between P and HAMD ,whereas a negative correlation between E2/P and HAMD was demonstrated. Conclusion The function of E2 and P secretion might be involved in the mechanism of perimenopausal depression disorder.