胱抑素C水平在随诊年轻过敏性紫癜患者肾脏损害变化中的价值分析

Analysis of Cystatin C Level Change in Young Patient with Henoch-Schonlein Purpura with the Renal Injury

目的:分析年轻过敏性紫癜(肾型)患者血清胱抑素叭CysC)水平变化的意义。方法:28名年轻过敏性紫癜(肾型)患者依涉及组织分为单纯肾型(皮肤及肾脏涉及)18例,复合型(除皮肤、肾脏涉及外,还涉及关节或消化道)10例;依初诊尿蛋白分为轻型组17例,重型组11例。采用乳胶颗粒增强透射免疫比浊法(PETIA)测定血清CysC水平,并与20例对照组比较分析。结果:单纯肾型组及复合肾型组CysC水平高于对照组(1.53mg/L、1.31mg/L,P<0.05),但两者差异并无显著性意义;轻型组及重型组CysC水平差异存在显著性意义(1.27mg/L、1.73mg/LP=0.006)。轻型组及重型组患者CysC水平在尿蛋白转阴后均仍保持相对高水平。结论:血清CysC的水平对过敏性紫癜肾损伤的评估和指导治疗方面具有良好的临床价值。

Objective To analysis the clinical value of vystatin C （ Cys C） level in the patients with renal injury caused by Henoch - Schonlein purpura. Methods Using latex particle enhanced transmission immunotur- bidimetry analytic （PETIA） technique to measure. The serum levels of Cys C in 28 patient with Henoch - Schonlein purpura. According to the involved organs,28 cases were assigned into simple group （18 cases, Only involved in skin and kidney） and complex group（ 10 cases, also involved in the joint and the digestivetract）. these 28 patients were also assigned into mild group and serious group by the level of urine protein. Results The levels of Cys C in the Simple group and Complex group were higher than those in control group （ 1.53 mg/L and 1.31 mg/L vs 0.89 mg/L P 〈 0.05 ）, The levels of Cys C in the Serious group were significantly higher than those in mild group （ 1.73 mg/L vs 1.27 mg/L P = 0.006）, the Serum Cys C levels in the mild and serious groups still were higher than in the control group when the urine protein become negative. Conelusion Serum Cys C has important clinical value in the assessment of renal injury and in the therapy guide inpatient with Henoch - Sehonlein purpura.