P3测试对血管性痴呆认知障碍的诊断价值分析

Analysis of P3 testing in the diagnosis of the cognitive dysfunction in vascular dementia

目的 研究血管性痴呆 (VD)病人P3测试参数的变化特点。方法 视觉分辨刺激序列测试 15例VD病人的P3,同时测查MMSE、数字广度 (DS)。结果 ①VD病人P3缺失率增加 ,潜伏期及波宽延长 ,波幅降低。②P3地形图显示VD病人顶中央区皮层激活范围明显减少 ,额区、颞区 (尤其左侧 )皮层激活不明显。③P3潜伏期与MMSE、DS得分有明显的相关性。结论 P3潜伏期是反映认知功能的关键指标 ,地形图可以形象地反映脑叶功能的变化。而P3检查与神经心理测查相结合 ,能更全面地反映认知功能的变化。

Objective To investigate the feature of P3 parameter in vascular dementia (VD) patients. Methods P3 was elicited in 15 VD patients by visual discrimination program,while MMSE and digit span (DS) were tested. Results ①The absent response of P3 increased to 20% in VD group.P3 latency with prolonged and amplitude decreased markedly.②Tomography in VD group showed that the activated region in parietal and central cortex reduced,greatly,without the evident activating of frontal and temporal cortex (especially left side).③P3 latency had a close correlation with the scores of MMSE and DS in VD group. Conclusions P3 latency is a key index to express the cognition,tomography can demonstrate the function of cortex.It is suggested that combining P3 with neuropsychological tests could well reflect the alteration of cognitive function.