凋亡抑制基因survivin与卵巢癌的研究新进展

The New Research Progress of Inhibitor of Apoptosis Genes and Ovarian Cancer

卵巢癌是女性生殖器官最常见的恶性肿瘤之一,其发病率高而存活率低,对女性的健康造成极大的威胁。尽管目前采用手术、化疗、放疗等治疗手段使卵巢癌的存活率有了很大提高,但晚期患者即使经过系统治疗达完全缓解,仍有很高的复发率。而耐药又是治疗失败的主要原因。Survivin是迄今发现的最强的凋亡抑制基因,其高表达使肿瘤细胞对多种化疗药物的耐受性增加,并介导肿瘤多药耐药的形成。鉴于survivin在卵巢癌细胞周期调控、凋亡与血管形成中的发挥着重要作用,探索各种新的分子生物学技术和基因治疗方法,阻断survivin表达而拮抗其抑制细胞凋亡的能力,降低细胞凋亡的阈值,恢复肿瘤细胞对化疗药物的敏感性,进而使卵巢癌获得根治成为可能,从而避免卵巢癌细胞耐药和转移扩散给病人带来的痛苦,具有深刻的指导意义。

Ovarian cancer is one of the most common malignant tumor of the female genital organs, and its high incidence and low survival rate, causing great threat to the health of women. Although surgery, chemotherapy, radiotherapy and other treatments have greatly improved the survival rate of ovarian cancer, but patients with advanced system for the treatment achieved complete remission, there is still a high relapse rate. Resistance is the main reason for treatment failure. Survivin is the strongest inhibitor of apoptosis genes discovered so far, its high expression of tumor ceils to increase the tolerance of a variety of chemotherapy drugs, and mediated tumor multidrug resistance formation. View of the regulation of survivin in ovarian cancer cell cycle, apoptosis and angiogenesis play an important role, to explore a variety of new molecular biology techniques and gene therapy methods, blocking survivin expression and antagonize the inhibition of apoptosis, reducing apoptosis threshold to restore the sensitivity of tumor cells to chemotherapeutic drugs, thereby enabling the ovarian cancer cure possible, in order to avoid ovarian cancer drug resistance and metastatic spread of the pain caused to the patient, profoundly instructive.