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外周血CD4＋CD25＋调节性T细胞在Graves病发病中的作用 被引量：1

On the role of peripheral blood CD4＋CD25＋ regulatory T ceLls in the pathogenesis of Graves＇ disease
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摘要 测定不同阶段Graves病患者外周血中淋巴细胞亚群含量及CD4＋CD25＋调节性T细胞功能。结果显示CD4＋CD25＋调节性T细胞免疫功能减弱导致CD4＋T细胞增殖失控可能是Graves病发病的重要原因，药物治愈患者其免疫功能难以完全恢复正常导致Graves病容易复发。 Lymphocyte subsets in peripheral blood and function of CD4＋CD25＋ regulatory T cells （Tregs） were assayed in patients during different periods of Graves＇ disease （GD）. Breakdown of Tregs＇ function lead to the wild proliferation of CD4＋T lymphocyte, and may play an important role in the pathogenesis of GD. It is difficult to fully restore the Tregs＇ function to normal after successful medication in Graves＇ disease, this phenomenon may lead to easy relapse of GD.
作者 查兵兵 刘军 洪晓武 查英 王芳 盛励 丁和远 陈灶萍 徐炯
机构地区 上海复旦大学附属上海市第五人民医院内分泌科 复旦大学免疫学系
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2012年第6期499-500,共2页 Chinese Journal of Endocrinology and Metabolism
基金 上海市闵行区卫生局科研基金（2009MW6）
关键词 格雷夫斯病 CD4+CD25+调节性T细胞 FOXP3 Graves disease CD4＋CD25＋ regulatory T cells Foxp3
分类号 R581.1 [医药卫生—内分泌]
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参考文献8

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二级参考文献7

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共引文献4

同被引文献14

  • 1Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic selftol- erance maintained by activated T cells expressing IL-2 receptor al- phachains (CD25). Breakdown of a single mechanism of self-tol- erance causes various autoimmune diseases [ J ]. Immunol, 1995, 155(3) :1151 -64.
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  • 6Mao C M, Wang S, Xiao Y C, et al. Impairment of regulatory ca- pacity of CIM + CD25 + regulatory T ceils mediated by dendritic cell polarization and hyperthyroidism in Graves' disease [ J ]. J Immunol,2011, 186(8): 4734-43.
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二级引证文献17

中华内分泌代谢杂志
2012年 第6期

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