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吡格列酮对肥胖大鼠脂肪甘油三酯脂酶表达的调控 被引量：4

Effects of pioglitazone on the expression of adipose triglyceride lipase in obese rats
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摘要 观察吡格列酮对高脂饮食诱导胰岛素抵抗大鼠脂肪、肝脏、肌肉三大组织脂肪甘油i酯脂酶（adipose trilycefide lipase，ATGL）表达的变化。结果显示吡格列酮促进胰岛素抵抗大鼠脂肪、肝脏、肌肉三大代谢组织中ATGL的表达。 To detect the effects ofpioglitazone on adipose triglyceride lipase（ATGL） in adipose, liver, and muscle of high-fat diet-induced obese rats. Insulin resistance and decreased expression of adipose triglyceride lipase were found in the adipose, liver, and muscle tissues. Pioglitazone may improve insulin sensitivity and ameliorate ATGL expression in tissues of high-fat diet-induced obese rats.
作者 祝超瑜 刘晓华 章建梅 徐淼 魏丽 贾伟平
机构地区 上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病研究所上海市糖尿病重点实验室上海市糖尿病临床医学中心
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2012年第6期509-511,共3页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金（30670989） 上海市糖尿病重点实验室项目（08DZ2230200）
关键词 脂肪甘油三酯脂酶 胰岛素抵抗 吡格列酮 Adipose triglyceride lipase Insulin resistance Pioglitazone
分类号 R587.1 [医药卫生—内分泌]
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参考文献14

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同被引文献22

  • 1陆伦根,曾民德,茅益民,万谟彬,李成忠,陈成伟,傅青春,王吉耀,佘为民,蔡雄,叶军,周霞秋,王晖,巫善明,唐美芳,朱金水,陈维雄.氧化苦参碱治疗慢性乙型肝炎的随机双盲对照多中心研究[J].中华肝脏病杂志,2004,12(10):597-600. 被引量：29
  • 2Kwak MK, Ha H. Where are we now in diabetic research? [J]. Arch Pharm Res, 2013, 36(2) :142 -144.
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  • 6Jenkins CM, Mancuso DJ, Yan W, et al. Identification, clo- ning, expression, and purification of three novel human calcium- independent phospholipase A2 family members possessing triacyl- glycerol lipase and aeylglycerol transacylase activities [ J]. J Biol Chem, 2004, 279(47): 48968-48975.
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二级引证文献6

中华内分泌代谢杂志
2012年 第6期

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