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IVF-ET中促性腺激素释放激素激动剂的超促排卵应用与剂量研究 被引量：13

Gonadotropin-releasing Hormone Agonist for Controlled Ovarian Hyperstimulation and Dose-finding Study in In Vitro Fertilization-Embryo Transfer
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摘要 促性腺激素释放激素激动剂(GnRH-a)是体外受精-胚胎移植(IVF-ET)技术中重要用药。GnRH-a与GnRH受体结合后,早期"突发"作用可刺激垂体促性腺激素急剧释放,持续应用后使垂体受抑制,内源性促性腺激素(Gn)水平下降,即所谓的降调节作用。利用这种生物学特性,GnRH-a联合Gn超促排卵可预防早发黄体生成素(LH)峰,避免卵泡过早黄素化。另外,GnRH-a代替人绒毛膜促性腺激素诱发排卵可降低卵巢过度刺激综合征(OHSS)发生率。探索既能有效抑制LH峰,又不使垂体过度抑制的GnRH-a有效低剂量对于超促排卵有重要意义。 Gonadotropin-releasing hormone agonist（GnRH-a） is one of the most effective drugs used for controlled ovarian hyperstimulation （COH） in in vitro fertilization-embryo transfer （IVF-ET）. The early ＂flare up＂ of GnRH-a can stimulate the sharp release of endogenous gonadotropins. Continuous administration of GnRH-a caused reversibly block of pituitary function and low level of endogenous gonadotropin, which is the so-called down-regulation. Thergfore, GnRH agonist protocol with exogenous gonadotropins can prevent a luteinizing hor- mone surge, premature oocyte maturation and luteinization. In addition, GnRH-a triggering which can take the place of hCG triggering leads to a significant reduction of OHSS rate. To explore the effective low dose of GnRH-a which can prevent a LH surge without excessive pituitary desensitization has a critical role for COH.
作者 郜虹媛 匡延平
机构地区 上海交通大学医学院附属第九人民医院 上海交通大学医学院九院临床医学院
出处 《生殖与避孕》 CAS CSCD 2012年第6期403-407,共5页 Reproduction and Contraception
关键词 促性腺激素释放激素激动剂(GnRH-a) 体外受精-胚胎移植(IVF-ET) 超促排卵 剂量研究 Gonadotropin-releasing hormone agonist（GnRH-a） in vitro fertilization and embryotransfer （IVF-ET） controlled ovarian hyperstimulation （COH）
分类号 R714.8 [医药卫生—妇产科学]
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参考文献27

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二级参考文献29

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共引文献39

同被引文献140

引证文献13

二级引证文献154

生殖与避孕
2012年 第6期

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