补佳乐联合复方氨维胶囊对薄型子宫内膜不孕症者妊娠结局的改善

Compound Amino Acid and Vitamin Capsules Combined with Estrogen Improved Pregnancy Rate of Infertile Women Suffering from Thin Endometrium

目的:探讨补佳乐联合复方氨维胶囊对子宫内膜厚度及妊娠率的影响。方法:经B超监测有排卵发生但子宫内膜厚度<7 mm的不孕患者,随机分为补佳乐组(月经第7日给予补佳乐至排卵后2周)、氨基酸组(以复方氨维胶囊代替补佳乐)及联合用药(同时服用补佳乐和复方氨维胶囊)组,观察内膜生长情况及妊娠率。结果:共纳入患者142例,补佳乐组46例,氨基酸组48例,联合用药组48例,3组患者用药后子宫内膜厚度均较服药前增加(6.11±0.62 mmvs 8.03±1.34 mm、6.09±0.57 mm vs 7.94±1.28 mm、6.08±0.76 mm vs 8.93±1.47 mm),差异均显著(P<0.05)。联合用药组服药前、后的子宫内膜增加幅度及妊娠率均高于补佳乐组及氨基酸组,差异显著(P<0.05)。结论:复方氨维胶囊联合补佳乐可一定程度提高子宫内膜厚度,有助于胚胎着床,增加妊娠率,从而改善妊娠结局。

Objective： To explore the influences of compound amino acid and vitamin capsules （CAAVC） combined with Progynova on endometrium thickness and pregnancy rate. Methods： After ultrasonography monitoring, infertile patients who can ovulate and whose endometrial thickness was less than 7 mm were randomly divided into 3 groups： Progynova group （Progynova was administered orally from day 7 of menstruation to 2 weeks after avulation）, CAAVC group （CAAVC was administered orally instead of Progynova） and combined group （Progynova＋CAAVC）. The patients in combined group were treated with CAAVC combined with progynova, the endometrial development pregnancy rate was observed. Results： A total of 142 infertile patients were collected, including 46 cases in progynova group, 48 cases in CAAVC group and 48 cases in combined group. The endometrial thickness increased significantly after treated with progynova, CAAVC or CAAVC combined with progynova （P〈0.05）. The endometria of patients in the combined group grew remarkably thicker than those in the other two groups （P〈0.05）. The pregnancy rate in combined group was higher than that in the other two groups （P〈0.05）. Conclusion： The therapy using CAAVC combined with progynova is good for the increase of endometrial thickness which facilitates embryo implantation, and eventually elevates pregnancy rate.