新疆金鸡菊提取物体外对α-葡萄糖苷酶的影响

Effect on α-glucosidase activity of Xinjiang Coreopsis ticntoria flowers extracts in vitro

目的:研究新疆金鸡菊五种提取物体外对α-葡萄糖苷酶活性的影响。方法:用醇提法并有机溶剂萃取法制备新疆金鸡菊5种提取物,用体外α-葡萄糖苷酶抑制模型对5种新疆金鸡菊提取物进行α-葡萄糖苷酶抑制活性筛选。结果:新疆金鸡菊的5种提取物体外对α-葡萄糖苷酶的活性均有抑制作用,其中提取物Ⅲ的IC50最低,活性最强。结论:在体外,新疆金鸡菊提取物在一定浓度下有抑制α-葡萄糖苷酶活性的作用。

Objective： To study the effect of Xinjiang Coreopsis ticntoria flowers （CTF） 5 extracts to α -glucosidase activity in vitro. Methods： 5 extracts of CTF were prepared by ethanol extraction and organic solvent abstraction method. To screen CTF 5 extracts which have great inhibitory effect on α - glucosidase by enzymatic method in vitro. Results： The extracts of CTF showed obviously inhibitory action against α - glucosidase activity. The extract II1 was the most effective to enzyme inhibition with the lowest IC50 in vitro. Conclusion ： Xinjiang Coriopsis ticntoria flowers extracts had remarkable inhibitory effect to α - glucosidase activity in vitro.