酒精性肝病患者健康相关生存质量研究

Assessing health-related quality of life in Chinese patients with alcoholic liver disease

目的研究酒精性肝病患者健康相关生存质量及其与疾病严重程度的关系以及对比酒精性肝病与慢性乙型肝炎患者健康相关生存质量的差别。方法 2010年12月至2011年10月收治的70例男性酒精性肝病患者(非肝硬化组45例,肝硬化组25例),56例男性慢性乙型肝炎患者(非肝硬化组24例,肝硬化组32例)以及42例男性健康对照组受试者参与试验。所有受试者回答SF-36V2(中文版)量表,通过SF-36V2软件计算出:生理功能、生理职能、躯体疼痛、总体健康、活力、社会功能、情感职能、精神健康共8个维度,以及躯体健康总评和精神健康总评。使用协方差分析对比健康对照组,酒精性肝病非肝硬化组,以及酒精性肝病肝硬化组健康相关生存质量;对比酒精性肝病与慢性乙型肝炎患者健康相关生存质量。结果和健康对照组相比,酒精性肝病患者随着疾病的加重,SF-36V2各维度评分明显降低(P<0.05)。酒精性肝病非肝硬化组患者较慢性乙型肝炎非肝硬化组患者仅生理功能、生理职能、活力、躯体健康总评四项评分轻度受损(P<0.05)。酒精性肝病肝硬化组与慢性乙型肝炎肝硬化组患者SF-36V2各维度评分相似(P>0.05)。结论酒精性肝病患者健康相关生存质量降低,且病情越重,健康相关生存质量越差。酒精性肝病患者健康相关生存质量与慢性乙型肝炎患者相似。

Objective To investigate health-related quality of life in Chinese patients with alcoholic liver disease and to compare health-related quality of life between patients with alcoholic liver disease and those with chronic： viral hepatitis B. Methods In this study, health-related quality of life was measured with the Medical Outcomes Study of Short Form SF-36 V2（ Chinese version ）. A total of 70 male Chinese patients with alcoholic liver disease （45 without cirrhosis ,25 with ein＇hosis ）, 56 male Chinese patients with chronic viral hepatitis B （24 without cirrhosis ,32 with cirrhosis ）, and 42 male healthy controls were enrolled in the study and answered the questionnaire of SF-36 v2 in Chinese. HRQOL scores of different groups were compared with univariate an＇,dysis. Results Compared with the healthy controls, patients with alcoholic liver disease had impaired health -related quality of＇ life. Increasing severity of disease from no cirrhosis to cirrhosis wa~ associated with a decrease on all domains of the SF-36V2 （ P 〈 O. 05 ）. Scores of physical functioning, role physical, vitality, and physical component summary in group of ＇alcoholic liver disease without cirrhosis were higher than those of chronic viral hepatitis B without cirrhosis （P 〈 0. 05 ）. Scores were similar between two groups with cirrhosis （ P 〉 O. 05 ）. Conclusions We conclude that patients with ＇alcoholic liver disease have impaired health -related quality of life, and increasing severity of disease is associated with a decrease on health -related quality of life. Patients with ＇alcoholic liver disease and chronic viral hepatitis B have similar health-related quality of life.