摘要
转位蛋白18 kDa曾命名为外周型苯二氮受体,2005年把曾称为外周型苯二氮受体的第一亚单位(DB1,18 kDA)重命名为TSPO。TSPO在中枢神经系统中主要分布于胶质细胞线粒体外膜,并在与甾体合成相关的组织中高度表达,参与甾体合成,细胞凋亡和免疫调节等生理调节,其表达与各种神经病变中的脑内炎症和反应性胶质化有关。TSPO配体在临床上具有诊断和治疗神经精神疾病的价值。本文阐述TSPO命名的由来和分子基本结构特征,在中枢神经系统中胶质细胞线粒体外膜的分布以及其参与神经类固醇合成、线粒体凋亡和免疫调节等生理功能,进一步综述现今TSPO配体用于诊断和治疗神经精神疾病的现状。
Translocator protein 18 kDa （TSPO） was previously known as the peripheral-type benzodiazepine receptor（PBR）. In 2005, the DBI 18 kDa, previously called the first subunit of PBR, was renamed TSPO. TSPO is primarily localized in outer mitochondrial membranes and highly expressed in the relevant tissues responsible for steroid synthesis. TSPO is closely associated with physiological regulation such as steroid synthesis, apoptosis, and immunomodulation. Moreover, TSPO expression is involved in the brain inflammation and reactive gliosis that is as- sociated with neuropsychiatric disorders. It has been indicated that TSPO ligands might be valuable in diagnosis and treatment of neuropsychiatric disorders. This review summaries the TSPO naming origin and its molecular structure, distribution localized at outer mitochondrial membranes and physiological regulation such as steroid synthesis, mito- chondrial apoptosis, immunomodulation as well as the current progress in using TSPO ligands for the diagnosis and treatment of neuropsychiatric disorders.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2012年第3期368-373,共6页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(81173036)~~
