EGFR和K-ras在肺癌中的表达及其临床意义

Expression and clinical significance of EGFR and K-ras in lung cancer

目的研究表皮生长因子受体(EGFR)和K-ras因子在不同组织学类型肺癌组织以及正常组织中的表达,探讨EGFR和K-ras因子在肺癌中的作用及其临床意义。方法收集不同类型的肺癌组织96例以及正常的肺组织96例,采用免疫组化法检测肺癌组织以及正常肺组织中EGFR和K-ras因子的表达。结果在96例肺癌组织中,EGFR在各型肺癌中高表达(阳性率为44.8%),在非小细胞肺癌(NSCLC)中,与组织学类型、淋巴结转移、性别、年龄相关(P<0.05),与分化程度无相关性;K-ras在各型肺癌中高表达(阳性率为78.1%),在NSCLC中,与组织学类型、淋巴结转移、年龄相关(P<0.05),与分化程度、性别无相关性;肺癌组织中EGFR和K-ras的表达具有反相关(P<0.05)。结论EGFR和K-ras在肺癌中的高表达可能促进肺癌的发生、发展。

Objective To investigate the differential expression of epidermal growth factor receptor （EGFR） and K-ras in tumor of the lung tissues and its clinical significance. Methods Immunohistoehemieal staining of EGFR and K-ras was performed in 96 cases of lung cancer and 96 cases of normal tissues. Results Positive rate of EG- FR in lung cancer （44. 8 % ） was significantly higher than that of the normal tissues, and was related to histological types, lymph node metastasis, gender and age （P 〈 0.05 ） , and was no correlated with differentiation. Positive rate of K-ras in lung cancer （78.1%） was significantly higher than that of the normal tissues, and was related to histological types, lymph node metastasis and age （ P 〈 0.05 ） , and was no correlated with differentiation and gender. Conclusion The overexpression of EGFR and K-ras are closely related to the formation and the development in the lung cancer.