剪切波弹性成像检测正常人及慢性肝病患者肝弹性模量

Measurement of hepatic elastic modulus of health control people and Chronic liver disease patients using shear wave elastography

目的探讨剪切波弹性成像应用于肝硬度检测的可行性。方法将剪切波弹性成像应用于95例健康对照者、70例肝纤维化患者和86例肝硬化患者肝弹性模量的检测。结果健康对照组和肝纤维化组成像成功率均为100％，肝硬化组稍低，健康对照组和肝纤维化组分别与肝硬化组成像成功率比较差异无统计学意义（P〉0．05）。健康对照组、肝纤维化组和肝硬化组的弹性模量比较及三组均数间的多重比较差异均有统计学意义（P〈0．05），弹性模量以健康对照组最低，肝硬化组最高，呈明显的上升趋势。结论剪切波弹性成像可应用于肝硬度的检测，对三组人群均能较好区分。

Objective To explore the feasibility of measurement of hepatic elastic modulus using shear wave elastography （SWE）. Methods Hepatic elastic modulus of 95 health control people, 70 liver fibrosis patients and 86 liver cirrhosis patients were measured by SWE. Results The success rate of imaging of health control people and liver cirrhosis patients were 100%, the success rate of liver fibrosis patients was a little lower,but there was no significant difference between control people and liver cirrhosis patients or fibrosis patients and liver cirrhosis patients （P 〉0.05）. The modulus of elasticity had a significant difference in health control people, liver fibrosis patients and liver cirrhosis patients （P 〈0.05）. The multiple parameter comparison of mean of three groups also showed a significant difference（ P 〈0.05）. The health control people had the lowest modulus of elasticity, the liver cirrhosis patients had the highest modulus of elasticity, there was an obvious upward trend. Conclusions SWE can be applied to the measurement of hepatic stiffness, it can better distinguish above three groups.